Immunologic manifestations of autophagy

Vojo Deretic; Tomonori Kimura; Graham Timmins; Pope Moseley; Santosh Chauhan; Michael Mandell

doi:10.1172/jci73945

Immunologic manifestations of autophagy

Vojo Deretic, Tomonori Kimura, Graham Timmins, Pope Moseley, Santosh Chauhan, Michael Mandell

Disease Systems Biology Program

100 Citationer (Scopus)

Abstract

The broad immunologic roles of autophagy span innate and adaptive immunity and are often manifested in inflammatory diseases. The immune effects of autophagy partially overlap with its roles in metabolism and cytoplasmic quality control but typically expand further afield to encompass unique immunologic adaptations. One of the best-appreciated manifestations of autophagy is protection against microbial invasion, but this is by no means limited to direct elimination of intracellular pathogens and includes a stratified array of nearly all principal immunologic processes. This Review summarizes the broad immunologic roles of autophagy. Furthermore, it uses the autophagic control of Mycobacterium tuberculosis as a paradigm to illustrate the breadth and complexity of the immune effects of autophagy.

Originalsprog	Engelsk
Tidsskrift	The Journal of Clinical Investigation
Vol/bind	125
Udgave nummer	1
Sider (fra-til)	75-84
Antal sider	10
ISSN	0021-9738
DOI	https://doi.org/10.1172/jci73945
Status	Udgivet - 2 jan. 2015

FN’s Verdensmål

Dette resultat bidrager til følgende verdensmål

Adgang til dokumentet

10.1172/jci73945

pdfForlagets udgivne version, 1,49 MB

Citationsformater

@article{00f4bd47fb3c495aafe3fd24b4625080,

title = "Immunologic manifestations of autophagy",

abstract = "The broad immunologic roles of autophagy span innate and adaptive immunity and are often manifested in inflammatory diseases. The immune effects of autophagy partially overlap with its roles in metabolism and cytoplasmic quality control but typically expand further afield to encompass unique immunologic adaptations. One of the best-appreciated manifestations of autophagy is protection against microbial invasion, but this is by no means limited to direct elimination of intracellular pathogens and includes a stratified array of nearly all principal immunologic processes. This Review summarizes the broad immunologic roles of autophagy. Furthermore, it uses the autophagic control of Mycobacterium tuberculosis as a paradigm to illustrate the breadth and complexity of the immune effects of autophagy. ",

keywords = "Adaptive Immunity, Animals, Autophagy, Host-Pathogen Interactions, Humans, Immunity, Innate, Inflammation/pathology, Mycobacterium tuberculosis/immunology, Phagocytosis, Tuberculosis/immunology",

author = "Vojo Deretic and Tomonori Kimura and Graham Timmins and Pope Moseley and Santosh Chauhan and Michael Mandell",

year = "2015",

month = jan,

day = "2",

doi = "10.1172/jci73945",

language = "English",

volume = "125",

pages = "75--84",

journal = "The Journal of Clinical Investigation",

issn = "0021-9738",

publisher = "American Society for Clinical Investigation",

number = "1",

}

TY - JOUR

T1 - Immunologic manifestations of autophagy

AU - Deretic, Vojo

AU - Kimura, Tomonori

AU - Timmins, Graham

AU - Moseley, Pope

AU - Chauhan, Santosh

AU - Mandell, Michael

PY - 2015/1/2

Y1 - 2015/1/2

N2 - The broad immunologic roles of autophagy span innate and adaptive immunity and are often manifested in inflammatory diseases. The immune effects of autophagy partially overlap with its roles in metabolism and cytoplasmic quality control but typically expand further afield to encompass unique immunologic adaptations. One of the best-appreciated manifestations of autophagy is protection against microbial invasion, but this is by no means limited to direct elimination of intracellular pathogens and includes a stratified array of nearly all principal immunologic processes. This Review summarizes the broad immunologic roles of autophagy. Furthermore, it uses the autophagic control of Mycobacterium tuberculosis as a paradigm to illustrate the breadth and complexity of the immune effects of autophagy.

AB - The broad immunologic roles of autophagy span innate and adaptive immunity and are often manifested in inflammatory diseases. The immune effects of autophagy partially overlap with its roles in metabolism and cytoplasmic quality control but typically expand further afield to encompass unique immunologic adaptations. One of the best-appreciated manifestations of autophagy is protection against microbial invasion, but this is by no means limited to direct elimination of intracellular pathogens and includes a stratified array of nearly all principal immunologic processes. This Review summarizes the broad immunologic roles of autophagy. Furthermore, it uses the autophagic control of Mycobacterium tuberculosis as a paradigm to illustrate the breadth and complexity of the immune effects of autophagy.

KW - Adaptive Immunity

KW - Animals

KW - Autophagy

KW - Host-Pathogen Interactions

KW - Humans

KW - Immunity, Innate

KW - Inflammation/pathology

KW - Mycobacterium tuberculosis/immunology

KW - Phagocytosis

KW - Tuberculosis/immunology

U2 - 10.1172/jci73945

DO - 10.1172/jci73945

M3 - Review

C2 - 25654553

SN - 0021-9738

VL - 125

SP - 75

EP - 84

JO - The Journal of Clinical Investigation

JF - The Journal of Clinical Investigation

IS - 1

ER -

Immunologic manifestations of autophagy

Abstract

FN’s Verdensmål

Adgang til dokumentet

Fingeraftryk

Citationsformater