Immunohistochemical localisation and developmental aspects of epidermal growth factor in the rat

L. Raaberg; E. Nexo; J. Damsgaard Mikkelsen; S. Seier Poulsen

doi:10.1007/BF00500636

Immunohistochemical localisation and developmental aspects of epidermal growth factor in the rat

L. Raaberg, E. Nexo, J. Damsgaard Mikkelsen, S. Seier Poulsen^*

^*Corresponding author for this work

48 Citations (Scopus)

Abstract

The tissue localisation and time of first appearance of Epidermal Growth Factor (EGF) in the developing rat were investigated by means of immunohistochemistry, radioimmunoassay and radioreceptor assay. In this study we were able to show, that EGF appears prenatally in the lung and the kidney from gestational day 19. Postnatally EGF was found also in the gastrointestinal tract, first in Brunner's glands of the duodenum (at birth), next in the Paneth cells (day 7), and finally in the submandibular glands (day 25). The immunohistochemical and radioreceptor results are consistent, whereas the radioimmunoassay detects EGF later and in smaller quantities, than does the radioreceptor assay. These differences will be discussed.

Original language	English
Journal	Histochemistry
Volume	89
Issue number	4
Pages (from-to)	351-356
Number of pages	6
ISSN	0301-5564
DOIs	https://doi.org/10.1007/BF00500636
Publication status	Published - 1 Jul 1988

Access to Document

10.1007/BF00500636

Cite this

@article{f26eabfdfef749e4b0053d55e5010f32,

title = "Immunohistochemical localisation and developmental aspects of epidermal growth factor in the rat",

abstract = "The tissue localisation and time of first appearance of Epidermal Growth Factor (EGF) in the developing rat were investigated by means of immunohistochemistry, radioimmunoassay and radioreceptor assay. In this study we were able to show, that EGF appears prenatally in the lung and the kidney from gestational day 19. Postnatally EGF was found also in the gastrointestinal tract, first in Brunner's glands of the duodenum (at birth), next in the Paneth cells (day 7), and finally in the submandibular glands (day 25). The immunohistochemical and radioreceptor results are consistent, whereas the radioimmunoassay detects EGF later and in smaller quantities, than does the radioreceptor assay. These differences will be discussed.",

author = "L. Raaberg and E. Nexo and Mikkelsen, {J. Damsgaard} and Poulsen, {S. Seier}",

year = "1988",

month = jul,

day = "1",

doi = "10.1007/BF00500636",

language = "English",

volume = "89",

pages = "351--356",

journal = "Histochemistry",

issn = "0301-5564",

publisher = "Springer",

number = "4",

}

TY - JOUR

T1 - Immunohistochemical localisation and developmental aspects of epidermal growth factor in the rat

AU - Raaberg, L.

AU - Nexo, E.

AU - Mikkelsen, J. Damsgaard

AU - Poulsen, S. Seier

PY - 1988/7/1

Y1 - 1988/7/1

N2 - The tissue localisation and time of first appearance of Epidermal Growth Factor (EGF) in the developing rat were investigated by means of immunohistochemistry, radioimmunoassay and radioreceptor assay. In this study we were able to show, that EGF appears prenatally in the lung and the kidney from gestational day 19. Postnatally EGF was found also in the gastrointestinal tract, first in Brunner's glands of the duodenum (at birth), next in the Paneth cells (day 7), and finally in the submandibular glands (day 25). The immunohistochemical and radioreceptor results are consistent, whereas the radioimmunoassay detects EGF later and in smaller quantities, than does the radioreceptor assay. These differences will be discussed.

AB - The tissue localisation and time of first appearance of Epidermal Growth Factor (EGF) in the developing rat were investigated by means of immunohistochemistry, radioimmunoassay and radioreceptor assay. In this study we were able to show, that EGF appears prenatally in the lung and the kidney from gestational day 19. Postnatally EGF was found also in the gastrointestinal tract, first in Brunner's glands of the duodenum (at birth), next in the Paneth cells (day 7), and finally in the submandibular glands (day 25). The immunohistochemical and radioreceptor results are consistent, whereas the radioimmunoassay detects EGF later and in smaller quantities, than does the radioreceptor assay. These differences will be discussed.

UR - http://www.scopus.com/inward/record.url?scp=0023882463&partnerID=8YFLogxK

U2 - 10.1007/BF00500636

DO - 10.1007/BF00500636

M3 - Journal article

C2 - 3261722

AN - SCOPUS:0023882463

SN - 0301-5564

VL - 89

SP - 351

EP - 356

JO - Histochemistry

JF - Histochemistry

IS - 4

ER -

Immunohistochemical localisation and developmental aspects of epidermal growth factor in the rat

Abstract

Access to Document

Other files and links

Fingerprint

Cite this