Immunohistochemical localisation and developmental aspects of epidermal growth factor in the rat

L. Raaberg; E. Nexo; J. Damsgaard Mikkelsen; S. Seier Poulsen

doi:10.1007/BF00500636

Immunohistochemical localisation and developmental aspects of epidermal growth factor in the rat

L. Raaberg, E. Nexo, J. Damsgaard Mikkelsen, S. Seier Poulsen^*

^*Corresponding author af dette arbejde

48 Citationer (Scopus)

Abstract

The tissue localisation and time of first appearance of Epidermal Growth Factor (EGF) in the developing rat were investigated by means of immunohistochemistry, radioimmunoassay and radioreceptor assay. In this study we were able to show, that EGF appears prenatally in the lung and the kidney from gestational day 19. Postnatally EGF was found also in the gastrointestinal tract, first in Brunner's glands of the duodenum (at birth), next in the Paneth cells (day 7), and finally in the submandibular glands (day 25). The immunohistochemical and radioreceptor results are consistent, whereas the radioimmunoassay detects EGF later and in smaller quantities, than does the radioreceptor assay. These differences will be discussed.

Originalsprog	Engelsk
Tidsskrift	Histochemistry
Vol/bind	89
Udgave nummer	4
Sider (fra-til)	351-356
Antal sider	6
ISSN	0301-5564
DOI	https://doi.org/10.1007/BF00500636
Status	Udgivet - 1 jul. 1988

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AU - Raaberg, L.

AU - Nexo, E.

AU - Mikkelsen, J. Damsgaard

AU - Poulsen, S. Seier

PY - 1988/7/1

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N2 - The tissue localisation and time of first appearance of Epidermal Growth Factor (EGF) in the developing rat were investigated by means of immunohistochemistry, radioimmunoassay and radioreceptor assay. In this study we were able to show, that EGF appears prenatally in the lung and the kidney from gestational day 19. Postnatally EGF was found also in the gastrointestinal tract, first in Brunner's glands of the duodenum (at birth), next in the Paneth cells (day 7), and finally in the submandibular glands (day 25). The immunohistochemical and radioreceptor results are consistent, whereas the radioimmunoassay detects EGF later and in smaller quantities, than does the radioreceptor assay. These differences will be discussed.

AB - The tissue localisation and time of first appearance of Epidermal Growth Factor (EGF) in the developing rat were investigated by means of immunohistochemistry, radioimmunoassay and radioreceptor assay. In this study we were able to show, that EGF appears prenatally in the lung and the kidney from gestational day 19. Postnatally EGF was found also in the gastrointestinal tract, first in Brunner's glands of the duodenum (at birth), next in the Paneth cells (day 7), and finally in the submandibular glands (day 25). The immunohistochemical and radioreceptor results are consistent, whereas the radioimmunoassay detects EGF later and in smaller quantities, than does the radioreceptor assay. These differences will be discussed.

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JO - Histochemistry

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Immunohistochemical localisation and developmental aspects of epidermal growth factor in the rat

Abstract

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