Immunisation against a serine protease inhibitor reduces intensity of Plasmodium berghei infection in mosquitoes

Andrew Richard Williams; Sara E Zakutansky; Kazutoyo Miura; Matthew J D Dicks; Thomas S Churcher; Kerry E Jewell; Aisling M Vaughan; Alison V Turner; Melissa C Kapulu; Kristin Michel; Carole A Long; Robert E Sinden; Adrian V S Hill; Simon J Draper; Sumi Biswas

doi:10.1016/j.ijpara.2013.06.004

Immunisation against a serine protease inhibitor reduces intensity of Plasmodium berghei infection in mosquitoes

Andrew Richard Williams, Sara E Zakutansky, Kazutoyo Miura, Matthew J D Dicks, Thomas S Churcher, Kerry E Jewell, Aisling M Vaughan, Alison V Turner, Melissa C Kapulu, Kristin Michel, Carole A Long, Robert E Sinden, Adrian V S Hill, Simon J Draper, Sumi Biswas

14 Citations (Scopus)

Abstract

The mosquito innate immune response is able to clear the majority of Plasmodium parasites. This immune clearance is controlled by a number of regulatory molecules including serine protease inhibitors (serpins). To determine whether such molecules could represent a novel target for a malaria transmission-blocking vaccine, we vaccinated mice with Anopheles gambiae serpin-2. Antibodies against Anopheles gambiae serpin-2 significantly reduced the infection of a heterologous Anopheles species (Anopheles stephensi) by Plasmodium berghei, however this effect was not observed with Plasmodium falciparum. Therefore, this approach of targeting regulatory molecules of the mosquito immune system may represent a novel approach to transmission-blocking malaria vaccines.

Original language	English
Journal	International Journal for Parasitology
Volume	43
Issue number	11
Pages (from-to)	869-874
ISSN	0020-7519
DOIs	https://doi.org/10.1016/j.ijpara.2013.06.004
Publication status	Published - Oct 2013
Externally published	Yes

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Williams, A. R., Zakutansky, S. E., Miura, K., Dicks, M. J. D., Churcher, T. S., Jewell, K. E., Vaughan, A. M., Turner, A. V., Kapulu, M. C., Michel, K., Long, C. A., Sinden, R. E., Hill, A. V. S., Draper, S. J., & Biswas, S. (2013). Immunisation against a serine protease inhibitor reduces intensity of Plasmodium berghei infection in mosquitoes. International Journal for Parasitology, 43(11), 869-874. https://doi.org/10.1016/j.ijpara.2013.06.004

Williams, AR, Zakutansky, SE, Miura, K, Dicks, MJD, Churcher, TS, Jewell, KE, Vaughan, AM, Turner, AV, Kapulu, MC, Michel, K, Long, CA, Sinden, RE, Hill, AVS, Draper, SJ & Biswas, S 2013, 'Immunisation against a serine protease inhibitor reduces intensity of Plasmodium berghei infection in mosquitoes', International Journal for Parasitology, vol. 43, no. 11, pp. 869-874. https://doi.org/10.1016/j.ijpara.2013.06.004

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title = "Immunisation against a serine protease inhibitor reduces intensity of Plasmodium berghei infection in mosquitoes",

abstract = "The mosquito innate immune response is able to clear the majority of Plasmodium parasites. This immune clearance is controlled by a number of regulatory molecules including serine protease inhibitors (serpins). To determine whether such molecules could represent a novel target for a malaria transmission-blocking vaccine, we vaccinated mice with Anopheles gambiae serpin-2. Antibodies against Anopheles gambiae serpin-2 significantly reduced the infection of a heterologous Anopheles species (Anopheles stephensi) by Plasmodium berghei, however this effect was not observed with Plasmodium falciparum. Therefore, this approach of targeting regulatory molecules of the mosquito immune system may represent a novel approach to transmission-blocking malaria vaccines.",

author = "Williams, {Andrew Richard} and Zakutansky, {Sara E} and Kazutoyo Miura and Dicks, {Matthew J D} and Churcher, {Thomas S} and Jewell, {Kerry E} and Vaughan, {Aisling M} and Turner, {Alison V} and Kapulu, {Melissa C} and Kristin Michel and Long, {Carole A} and Sinden, {Robert E} and Hill, {Adrian V S} and Draper, {Simon J} and Sumi Biswas",

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doi = "10.1016/j.ijpara.2013.06.004",

language = "English",

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AU - Williams, Andrew Richard

AU - Zakutansky, Sara E

AU - Miura, Kazutoyo

AU - Dicks, Matthew J D

AU - Churcher, Thomas S

AU - Jewell, Kerry E

AU - Vaughan, Aisling M

AU - Turner, Alison V

AU - Kapulu, Melissa C

AU - Michel, Kristin

AU - Long, Carole A

AU - Sinden, Robert E

AU - Hill, Adrian V S

AU - Draper, Simon J

AU - Biswas, Sumi

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AB - The mosquito innate immune response is able to clear the majority of Plasmodium parasites. This immune clearance is controlled by a number of regulatory molecules including serine protease inhibitors (serpins). To determine whether such molecules could represent a novel target for a malaria transmission-blocking vaccine, we vaccinated mice with Anopheles gambiae serpin-2. Antibodies against Anopheles gambiae serpin-2 significantly reduced the infection of a heterologous Anopheles species (Anopheles stephensi) by Plasmodium berghei, however this effect was not observed with Plasmodium falciparum. Therefore, this approach of targeting regulatory molecules of the mosquito immune system may represent a novel approach to transmission-blocking malaria vaccines.

U2 - 10.1016/j.ijpara.2013.06.004

DO - 10.1016/j.ijpara.2013.06.004

M3 - Journal article

C2 - 23872520

SN - 0020-7519

VL - 43

SP - 869

EP - 874

JO - International Journal for Parasitology

JF - International Journal for Parasitology

IS - 11

ER -

Immunisation against a serine protease inhibitor reduces intensity of Plasmodium berghei infection in mosquitoes

Abstract

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