Identifying neuropeptide and protein hormone receptors in Drosophila melanogaster by exploiting genomic data.

Frank Hauser; Michael Williamson; Giuseppe Cazzamali; Cornelis J P Grimmelikhuijzen

doi:10.1093/bfgp/eli003

Identifying neuropeptide and protein hormone receptors in Drosophila melanogaster by exploiting genomic data.

Frank Hauser, Michael Williamson, Giuseppe Cazzamali, Cornelis J P Grimmelikhuijzen

Cell and Neurobiology

57 Citations (Scopus)

Abstract

Most neuropeptide and protein hormone receptors belong to the large superfamily of G-protein-coupled receptors (GPCRs). These cell membrane proteins steer many important processes such as development, reproduction, homeostasis and behaviour when activated by their corresponding ligands. The first insect genome, that of the fruitfly Drosophila melanogaster, was sequenced in 2000, and about 200 GPCRs have been annnotated in this model insect. About 50 of these receptors were predicted to have neuropeptides or protein hormones as their ligands. Since 2000, the cDNAs of most of these candidate receptors have been cloned and for many receptors the endogenous ligand has been identified. In this review, we will give an update about the current knowledge of all Drosophila neuropeptide and protein hormone receptors, and discuss their phylogenetic relationships.
Udgivelsesdato: 2006-Feb

Original language	English
Journal	Briefings in Functional Genomics and Proteomics
Volume	4
Issue number	4
Pages (from-to)	321-30
Number of pages	9
ISSN	1473-9550
DOIs	https://doi.org/10.1093/bfgp/eli003
Publication status	Published - 2006

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10.1093/bfgp/eli003

Cite this

@article{b56224e0ec2711dcbee902004c4f4f50,

title = "Identifying neuropeptide and protein hormone receptors in Drosophila melanogaster by exploiting genomic data.",

abstract = "Most neuropeptide and protein hormone receptors belong to the large superfamily of G-protein-coupled receptors (GPCRs). These cell membrane proteins steer many important processes such as development, reproduction, homeostasis and behaviour when activated by their corresponding ligands. The first insect genome, that of the fruitfly Drosophila melanogaster, was sequenced in 2000, and about 200 GPCRs have been annnotated in this model insect. About 50 of these receptors were predicted to have neuropeptides or protein hormones as their ligands. Since 2000, the cDNAs of most of these candidate receptors have been cloned and for many receptors the endogenous ligand has been identified. In this review, we will give an update about the current knowledge of all Drosophila neuropeptide and protein hormone receptors, and discuss their phylogenetic relationships. Udgivelsesdato: 2006-Feb",

author = "Frank Hauser and Michael Williamson and Giuseppe Cazzamali and Grimmelikhuijzen, {Cornelis J P}",

note = "Keywords: Animals; Drosophila Proteins; Drosophila melanogaster; Genome, Insect; Phylogeny; Receptors, G-Protein-Coupled; Receptors, Invertebrate Peptide; Receptors, Neuropeptide; Receptors, Steroid",

year = "2006",

doi = "10.1093/bfgp/eli003",

language = "English",

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T1 - Identifying neuropeptide and protein hormone receptors in Drosophila melanogaster by exploiting genomic data.

AU - Hauser, Frank

AU - Williamson, Michael

AU - Cazzamali, Giuseppe

AU - Grimmelikhuijzen, Cornelis J P

N1 - Keywords: Animals; Drosophila Proteins; Drosophila melanogaster; Genome, Insect; Phylogeny; Receptors, G-Protein-Coupled; Receptors, Invertebrate Peptide; Receptors, Neuropeptide; Receptors, Steroid

PY - 2006

Y1 - 2006

N2 - Most neuropeptide and protein hormone receptors belong to the large superfamily of G-protein-coupled receptors (GPCRs). These cell membrane proteins steer many important processes such as development, reproduction, homeostasis and behaviour when activated by their corresponding ligands. The first insect genome, that of the fruitfly Drosophila melanogaster, was sequenced in 2000, and about 200 GPCRs have been annnotated in this model insect. About 50 of these receptors were predicted to have neuropeptides or protein hormones as their ligands. Since 2000, the cDNAs of most of these candidate receptors have been cloned and for many receptors the endogenous ligand has been identified. In this review, we will give an update about the current knowledge of all Drosophila neuropeptide and protein hormone receptors, and discuss their phylogenetic relationships. Udgivelsesdato: 2006-Feb

AB - Most neuropeptide and protein hormone receptors belong to the large superfamily of G-protein-coupled receptors (GPCRs). These cell membrane proteins steer many important processes such as development, reproduction, homeostasis and behaviour when activated by their corresponding ligands. The first insect genome, that of the fruitfly Drosophila melanogaster, was sequenced in 2000, and about 200 GPCRs have been annnotated in this model insect. About 50 of these receptors were predicted to have neuropeptides or protein hormones as their ligands. Since 2000, the cDNAs of most of these candidate receptors have been cloned and for many receptors the endogenous ligand has been identified. In this review, we will give an update about the current knowledge of all Drosophila neuropeptide and protein hormone receptors, and discuss their phylogenetic relationships. Udgivelsesdato: 2006-Feb

U2 - 10.1093/bfgp/eli003

DO - 10.1093/bfgp/eli003

M3 - Journal article

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