Identification of a pegivirus (GB virus-like virus) that infects horses

TY - JOUR

T1 - Identification of a pegivirus (GB virus-like virus) that infects horses

AU - Kapoor, Amit

AU - Simmonds, Peter

AU - Cullen, John M

AU - Scheel, Troels K H

AU - Medina, Jan L

AU - Giannitti, Federico

AU - Nishiuchi, Eiko

AU - Brock, Kenny V

AU - Burbelo, Peter D

AU - Rice, Charles M

AU - Lipkin, W Ian

PY - 2013/6

Y1 - 2013/6

N2 - The recent identification of nonprimate hepaciviruses in dogs and then in horses prompted us to look for pegiviruses (GB virus-like viruses) in these species. Although none were detected in canines, we found widespread natural infection of horses by a novel pegivirus. Unique genomic features and phylogenetic analyses confirmed that the tentatively named equine pegivirus (EPgV) represents a novel species within the Pegivirus genus. We also determined that EPgV causes persistent viremia whereas its clinical significance is undetermined.

AB - The recent identification of nonprimate hepaciviruses in dogs and then in horses prompted us to look for pegiviruses (GB virus-like viruses) in these species. Although none were detected in canines, we found widespread natural infection of horses by a novel pegivirus. Unique genomic features and phylogenetic analyses confirmed that the tentatively named equine pegivirus (EPgV) represents a novel species within the Pegivirus genus. We also determined that EPgV causes persistent viremia whereas its clinical significance is undetermined.

KW - Amino Acid Sequence

KW - Animals

KW - Base Sequence

KW - Flaviviridae

KW - Flaviviridae Infections

KW - Horse Diseases

KW - Horses

KW - Molecular Sequence Data

KW - Phylogeny

KW - Prevalence

KW - Sequence Analysis, DNA

KW - Species Specificity

KW - United States

KW - Viremia

U2 - 10.1128/JVI.00324-13

DO - 10.1128/JVI.00324-13

M3 - Journal article

C2 - 23596285

SN - 0022-538X

VL - 87

SP - 7185

EP - 7190

JO - Journal of Virology

JF - Journal of Virology

IS - 12

ER -