Identification and characterization of a small-molecule inhibitor of death-associated protein kinase 1

TY - JOUR

T1 - Identification and characterization of a small-molecule inhibitor of death-associated protein kinase 1

AU - Wilbek, Theis S

AU - Skovgaard, Tine

AU - Sorrell, Fiona J

AU - Knapp, Stefan

AU - Berthelsen, Jens

AU - Strømgaard, Kristian

PY - 2015/1/2

Y1 - 2015/1/2

N2 - A novel imidazo-pyramidazine inhibitor of DAPK1 that undergoes class-specific interactions and extends into the substrate recognition site has been identified. This inhibitor is a good starting point for the development of selective and potent inhibitors of DAPK1, with potential use against stroke and ischemia.

AB - A novel imidazo-pyramidazine inhibitor of DAPK1 that undergoes class-specific interactions and extends into the substrate recognition site has been identified. This inhibitor is a good starting point for the development of selective and potent inhibitors of DAPK1, with potential use against stroke and ischemia.

U2 - 10.1002/cbic.201402512

DO - 10.1002/cbic.201402512

M3 - Journal article

C2 - 25382253

SN - 1439-4227

VL - 16

SP - 59

EP - 63

JO - ChemBioChem

JF - ChemBioChem

IS - 1

ER -