Hypoxic signalling in tumour stroma

Anu Laitala; Janine T. Erler

doi:10.3389/fonc.2018.00189

Hypoxic signalling in tumour stroma

Anu Laitala, Janine T. Erler^*

^*Corresponding author for this work

26 Citations (Scopus)

59 Downloads (Pure)

Abstract

Hypoxia is a common feature in solid tumors and is associated with cancer progression. The main regulators of the hypoxic response are hypoxia-inducible transcription factors (HIFs) that guide the cellular adaptation to hypoxia by gene activation. The actual oxygen sensing is performed by HIF prolyl hydroxylases (PHDs) that under normoxic conditions mark the HIF-α subunit for degradation. Cancer progression is not regulated only by the cancer cells themselves but also by the whole tumor microenvironment, which consists of cellular and extracellular components. Hypoxic conditions also affect the stromal compartment, where stromal cells are in close contact with the cancer cells. The important function of HIF in cancer cells has been shown by many animal models and described in hundreds of reviews, but less in known about PHDs and even less PHDs in stromal cells. Here, we review hypoxic signaling in tumors, mainly in the tumor stroma, with a focus on HIFs and PHDs.

Original language	English
Article number	189
Journal	Frontiers in Oncology
Volume	8
Pages (from-to)	1-13
Number of pages	13
ISSN	2234-943X
DOIs	https://doi.org/10.3389/fonc.2018.00189
Publication status	Published - 2018

Keywords

HIF
Hypoxia
Metastasis
PHDs
Tumour stroma

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3389/fonc.2018.00189Licence: CC BY

Hypoxic Signalling in Tumour StromaFinal published version, 1.43 MBLicence: CC BY

Cite this

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title = "Hypoxic signalling in tumour stroma",

abstract = "Hypoxia is a common feature in solid tumors and is associated with cancer progression. The main regulators of the hypoxic response are hypoxia-inducible transcription factors (HIFs) that guide the cellular adaptation to hypoxia by gene activation. The actual oxygen sensing is performed by HIF prolyl hydroxylases (PHDs) that under normoxic conditions mark the HIF-α subunit for degradation. Cancer progression is not regulated only by the cancer cells themselves but also by the whole tumor microenvironment, which consists of cellular and extracellular components. Hypoxic conditions also affect the stromal compartment, where stromal cells are in close contact with the cancer cells. The important function of HIF in cancer cells has been shown by many animal models and described in hundreds of reviews, but less in known about PHDs and even less PHDs in stromal cells. Here, we review hypoxic signaling in tumors, mainly in the tumor stroma, with a focus on HIFs and PHDs.",

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T1 - Hypoxic signalling in tumour stroma

AU - Laitala, Anu

AU - Erler, Janine T.

PY - 2018

Y1 - 2018

N2 - Hypoxia is a common feature in solid tumors and is associated with cancer progression. The main regulators of the hypoxic response are hypoxia-inducible transcription factors (HIFs) that guide the cellular adaptation to hypoxia by gene activation. The actual oxygen sensing is performed by HIF prolyl hydroxylases (PHDs) that under normoxic conditions mark the HIF-α subunit for degradation. Cancer progression is not regulated only by the cancer cells themselves but also by the whole tumor microenvironment, which consists of cellular and extracellular components. Hypoxic conditions also affect the stromal compartment, where stromal cells are in close contact with the cancer cells. The important function of HIF in cancer cells has been shown by many animal models and described in hundreds of reviews, but less in known about PHDs and even less PHDs in stromal cells. Here, we review hypoxic signaling in tumors, mainly in the tumor stroma, with a focus on HIFs and PHDs.

AB - Hypoxia is a common feature in solid tumors and is associated with cancer progression. The main regulators of the hypoxic response are hypoxia-inducible transcription factors (HIFs) that guide the cellular adaptation to hypoxia by gene activation. The actual oxygen sensing is performed by HIF prolyl hydroxylases (PHDs) that under normoxic conditions mark the HIF-α subunit for degradation. Cancer progression is not regulated only by the cancer cells themselves but also by the whole tumor microenvironment, which consists of cellular and extracellular components. Hypoxic conditions also affect the stromal compartment, where stromal cells are in close contact with the cancer cells. The important function of HIF in cancer cells has been shown by many animal models and described in hundreds of reviews, but less in known about PHDs and even less PHDs in stromal cells. Here, we review hypoxic signaling in tumors, mainly in the tumor stroma, with a focus on HIFs and PHDs.

KW - HIF

KW - Hypoxia

KW - Metastasis

KW - PHDs

KW - Tumour stroma

U2 - 10.3389/fonc.2018.00189

DO - 10.3389/fonc.2018.00189

M3 - Review

C2 - 29896451

AN - SCOPUS:85047658467

SN - 2234-943X

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SP - 1

EP - 13

JO - Frontiers in Oncology

JF - Frontiers in Oncology

M1 - 189

ER -

Hypoxic signalling in tumour stroma

Abstract

Keywords

UN SDGs

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