Hypoxic signalling in tumour stroma

Anu Laitala; Janine T. Erler

doi:10.3389/fonc.2018.00189

Hypoxic signalling in tumour stroma

Anu Laitala, Janine T. Erler^*

^*Corresponding author af dette arbejde

26 Citationer (Scopus)

59 Downloads (Pure)

Abstract

Hypoxia is a common feature in solid tumors and is associated with cancer progression. The main regulators of the hypoxic response are hypoxia-inducible transcription factors (HIFs) that guide the cellular adaptation to hypoxia by gene activation. The actual oxygen sensing is performed by HIF prolyl hydroxylases (PHDs) that under normoxic conditions mark the HIF-α subunit for degradation. Cancer progression is not regulated only by the cancer cells themselves but also by the whole tumor microenvironment, which consists of cellular and extracellular components. Hypoxic conditions also affect the stromal compartment, where stromal cells are in close contact with the cancer cells. The important function of HIF in cancer cells has been shown by many animal models and described in hundreds of reviews, but less in known about PHDs and even less PHDs in stromal cells. Here, we review hypoxic signaling in tumors, mainly in the tumor stroma, with a focus on HIFs and PHDs.

Originalsprog	Engelsk
Artikelnummer	189
Tidsskrift	Frontiers in Oncology
Vol/bind	8
Sider (fra-til)	1-13
Antal sider	13
ISSN	2234-943X
DOI	https://doi.org/10.3389/fonc.2018.00189
Status	Udgivet - 2018

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10.3389/fonc.2018.00189Licens: CC BY

Hypoxic Signalling in Tumour StromaForlagets udgivne version, 1,43 MBLicens: CC BY

Citationsformater

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title = "Hypoxic signalling in tumour stroma",

abstract = "Hypoxia is a common feature in solid tumors and is associated with cancer progression. The main regulators of the hypoxic response are hypoxia-inducible transcription factors (HIFs) that guide the cellular adaptation to hypoxia by gene activation. The actual oxygen sensing is performed by HIF prolyl hydroxylases (PHDs) that under normoxic conditions mark the HIF-α subunit for degradation. Cancer progression is not regulated only by the cancer cells themselves but also by the whole tumor microenvironment, which consists of cellular and extracellular components. Hypoxic conditions also affect the stromal compartment, where stromal cells are in close contact with the cancer cells. The important function of HIF in cancer cells has been shown by many animal models and described in hundreds of reviews, but less in known about PHDs and even less PHDs in stromal cells. Here, we review hypoxic signaling in tumors, mainly in the tumor stroma, with a focus on HIFs and PHDs.",

keywords = "HIF, Hypoxia, Metastasis, PHDs, Tumour stroma",

author = "Anu Laitala and Erler, {Janine T.}",

year = "2018",

doi = "10.3389/fonc.2018.00189",

language = "English",

volume = "8",

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journal = "Frontiers in Oncology",

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TY - JOUR

T1 - Hypoxic signalling in tumour stroma

AU - Laitala, Anu

AU - Erler, Janine T.

PY - 2018

Y1 - 2018

N2 - Hypoxia is a common feature in solid tumors and is associated with cancer progression. The main regulators of the hypoxic response are hypoxia-inducible transcription factors (HIFs) that guide the cellular adaptation to hypoxia by gene activation. The actual oxygen sensing is performed by HIF prolyl hydroxylases (PHDs) that under normoxic conditions mark the HIF-α subunit for degradation. Cancer progression is not regulated only by the cancer cells themselves but also by the whole tumor microenvironment, which consists of cellular and extracellular components. Hypoxic conditions also affect the stromal compartment, where stromal cells are in close contact with the cancer cells. The important function of HIF in cancer cells has been shown by many animal models and described in hundreds of reviews, but less in known about PHDs and even less PHDs in stromal cells. Here, we review hypoxic signaling in tumors, mainly in the tumor stroma, with a focus on HIFs and PHDs.

AB - Hypoxia is a common feature in solid tumors and is associated with cancer progression. The main regulators of the hypoxic response are hypoxia-inducible transcription factors (HIFs) that guide the cellular adaptation to hypoxia by gene activation. The actual oxygen sensing is performed by HIF prolyl hydroxylases (PHDs) that under normoxic conditions mark the HIF-α subunit for degradation. Cancer progression is not regulated only by the cancer cells themselves but also by the whole tumor microenvironment, which consists of cellular and extracellular components. Hypoxic conditions also affect the stromal compartment, where stromal cells are in close contact with the cancer cells. The important function of HIF in cancer cells has been shown by many animal models and described in hundreds of reviews, but less in known about PHDs and even less PHDs in stromal cells. Here, we review hypoxic signaling in tumors, mainly in the tumor stroma, with a focus on HIFs and PHDs.

KW - HIF

KW - Hypoxia

KW - Metastasis

KW - PHDs

KW - Tumour stroma

U2 - 10.3389/fonc.2018.00189

DO - 10.3389/fonc.2018.00189

M3 - Review

C2 - 29896451

AN - SCOPUS:85047658467

SN - 2234-943X

VL - 8

SP - 1

EP - 13

JO - Frontiers in Oncology

JF - Frontiers in Oncology

M1 - 189

ER -

Hypoxic signalling in tumour stroma

Abstract

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