Hypoxia-inducible factors - regulation, role and comparative aspects in tumourigenesis

A E Hansen; A T Kristensen; I Law; Jesper Tranekjær Jørgensen; S A Engelholm

doi:10.1111/j.1476-5829.2010.00233.x

Hypoxia-inducible factors - regulation, role and comparative aspects in tumourigenesis

A E Hansen, A T Kristensen, I Law, Jesper Tranekjær Jørgensen, S A Engelholm

Cluster for Molecular Imaging

14 Citations (Scopus)

Abstract

Hypoxia-inducible factors (HIFs) play a key role in the cellular response experienced in hypoxic tumours, mediating adaptive responses that allow hypoxic cells to survive in the hostile environment. Identification and understanding of tumour hypoxia and the influence on cellular processes carries important prognostic information and may help identify potential hypoxia circumventing and targeting strategies. This review summarizes current knowledge on HIF regulation and function in tumour cells and discusses the aspects of using companion animals as comparative spontaneous cancer models. Spontaneous tumours in companion animals hold a great research potential for the evaluation and understanding of tumour hypoxia and in the development of hypoxia-targeting therapeutics.

Original language	English
Journal	Veterinary and Comparative Oncology
Volume	9
Issue number	1
Pages (from-to)	16-37
Number of pages	22
ISSN	1476-5810
DOIs	https://doi.org/10.1111/j.1476-5829.2010.00233.x
Publication status	Published - Mar 2011

Keywords

Animals
Basic Helix-Loop-Helix Transcription Factors
Cat Diseases
Cats
Cell Hypoxia
Disease Models, Animal
Dog Diseases
Dogs
Hypoxia-Inducible Factor 1
MicroRNAs
Neoplasms
Neoplastic Stem Cells

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1476-5829.2010.00233.x

Cite this

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abstract = "Hypoxia-inducible factors (HIFs) play a key role in the cellular response experienced in hypoxic tumours, mediating adaptive responses that allow hypoxic cells to survive in the hostile environment. Identification and understanding of tumour hypoxia and the influence on cellular processes carries important prognostic information and may help identify potential hypoxia circumventing and targeting strategies. This review summarizes current knowledge on HIF regulation and function in tumour cells and discusses the aspects of using companion animals as comparative spontaneous cancer models. Spontaneous tumours in companion animals hold a great research potential for the evaluation and understanding of tumour hypoxia and in the development of hypoxia-targeting therapeutics.",

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AU - Hansen, A E

AU - Kristensen, A T

AU - Law, I

AU - Jørgensen, Jesper Tranekjær

AU - Engelholm, S A

PY - 2011/3

Y1 - 2011/3

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AB - Hypoxia-inducible factors (HIFs) play a key role in the cellular response experienced in hypoxic tumours, mediating adaptive responses that allow hypoxic cells to survive in the hostile environment. Identification and understanding of tumour hypoxia and the influence on cellular processes carries important prognostic information and may help identify potential hypoxia circumventing and targeting strategies. This review summarizes current knowledge on HIF regulation and function in tumour cells and discusses the aspects of using companion animals as comparative spontaneous cancer models. Spontaneous tumours in companion animals hold a great research potential for the evaluation and understanding of tumour hypoxia and in the development of hypoxia-targeting therapeutics.

KW - Animals

KW - Basic Helix-Loop-Helix Transcription Factors

KW - Cat Diseases

KW - Cats

KW - Cell Hypoxia

KW - Disease Models, Animal

KW - Dog Diseases

KW - Dogs

KW - Hypoxia-Inducible Factor 1

KW - MicroRNAs

KW - Neoplasms

KW - Neoplastic Stem Cells

U2 - 10.1111/j.1476-5829.2010.00233.x

DO - 10.1111/j.1476-5829.2010.00233.x

M3 - Journal article

C2 - 21303451

SN - 1476-5810

VL - 9

SP - 16

EP - 37

JO - Veterinary and Comparative Oncology

JF - Veterinary and Comparative Oncology

IS - 1

ER -

Hypoxia-inducible factors - regulation, role and comparative aspects in tumourigenesis

Abstract

Keywords

UN SDGs

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