Hypoxia-inducible factors - regulation, role and comparative aspects in tumourigenesis

TY - JOUR

T1 - Hypoxia-inducible factors - regulation, role and comparative aspects in tumourigenesis

AU - Hansen, A E

AU - Kristensen, A T

AU - Law, I

AU - Jørgensen, Jesper Tranekjær

AU - Engelholm, S A

N1 - © 2010 Blackwell Publishing Ltd.

PY - 2011/3

Y1 - 2011/3

N2 - Hypoxia-inducible factors (HIFs) play a key role in the cellular response experienced in hypoxic tumours, mediating adaptive responses that allow hypoxic cells to survive in the hostile environment. Identification and understanding of tumour hypoxia and the influence on cellular processes carries important prognostic information and may help identify potential hypoxia circumventing and targeting strategies. This review summarizes current knowledge on HIF regulation and function in tumour cells and discusses the aspects of using companion animals as comparative spontaneous cancer models. Spontaneous tumours in companion animals hold a great research potential for the evaluation and understanding of tumour hypoxia and in the development of hypoxia-targeting therapeutics.

AB - Hypoxia-inducible factors (HIFs) play a key role in the cellular response experienced in hypoxic tumours, mediating adaptive responses that allow hypoxic cells to survive in the hostile environment. Identification and understanding of tumour hypoxia and the influence on cellular processes carries important prognostic information and may help identify potential hypoxia circumventing and targeting strategies. This review summarizes current knowledge on HIF regulation and function in tumour cells and discusses the aspects of using companion animals as comparative spontaneous cancer models. Spontaneous tumours in companion animals hold a great research potential for the evaluation and understanding of tumour hypoxia and in the development of hypoxia-targeting therapeutics.

KW - Animals

KW - Basic Helix-Loop-Helix Transcription Factors

KW - Cat Diseases

KW - Cats

KW - Cell Hypoxia

KW - Disease Models, Animal

KW - Dog Diseases

KW - Dogs

KW - Hypoxia-Inducible Factor 1

KW - MicroRNAs

KW - Neoplasms

KW - Neoplastic Stem Cells

U2 - 10.1111/j.1476-5829.2010.00233.x

DO - 10.1111/j.1476-5829.2010.00233.x

M3 - Journal article

C2 - 21303451

SN - 1476-5810

VL - 9

SP - 16

EP - 37

JO - Veterinary and Comparative Oncology

JF - Veterinary and Comparative Oncology

IS - 1

ER -