TY - JOUR
T1 - Hypoxia and oxidation levels of DNA and lipids in humans and animal experimental models
AU - Møller, Peter
AU - Risom, Lotte
AU - Lundby, Carsten
AU - Mikkelsen, Lone
AU - Loft, Steffen
N1 - Keywords: Altitude; Animals; Anoxia; Antioxidants; Biological Markers; DNA Damage; Exercise; Humans; Lipid Peroxidation; Models, Animal; Models, Theoretical; Oxidation-Reduction; Oxidative Stress
PY - 2008
Y1 - 2008
N2 - The objective of this review was to evaluate the association between hypoxia and oxidative damage to DNA and lipids. Evaluation criteria encompassed specificity and validation status of the biomarkers, study design, strength of the association, dose-response relationship, biological plausibility, analogous exposures, and effect modification by intervention. The collective interpretation indicates persuasive evidence from the studies in humans for an association between hypoxia and elevated levels of oxidative damage to DNA and lipids. The levels of oxidatively generated DNA lesions and lipid peroxidation products depend on both the duration and severity of the exposure to hypoxia. Largest effects are observed with exposure to hypoxia at high altitude, but other factors, including ultraviolet light, exercise, exertion, and low intake of antioxidants, might contribute to the effect observed in subjects at high altitude. Most of the animal experimental models should be interpreted with caution because the assays for assessment of lipid peroxidation products have suboptimal validity.
AB - The objective of this review was to evaluate the association between hypoxia and oxidative damage to DNA and lipids. Evaluation criteria encompassed specificity and validation status of the biomarkers, study design, strength of the association, dose-response relationship, biological plausibility, analogous exposures, and effect modification by intervention. The collective interpretation indicates persuasive evidence from the studies in humans for an association between hypoxia and elevated levels of oxidative damage to DNA and lipids. The levels of oxidatively generated DNA lesions and lipid peroxidation products depend on both the duration and severity of the exposure to hypoxia. Largest effects are observed with exposure to hypoxia at high altitude, but other factors, including ultraviolet light, exercise, exertion, and low intake of antioxidants, might contribute to the effect observed in subjects at high altitude. Most of the animal experimental models should be interpreted with caution because the assays for assessment of lipid peroxidation products have suboptimal validity.
U2 - 10.1002/iub.109
DO - 10.1002/iub.109
M3 - Journal article
C2 - 18698611
SN - 1521-6543
VL - 60
SP - 707
EP - 723
JO - IUBMB Life
JF - IUBMB Life
IS - 11
ER -