Hypoglycemia-Associated EEG Changes Following Antecedent Hypoglycemia in Type 1 Diabetes Mellitus

Anne-Sophie Sejling; Troels W Kjaer; Ulrik Pedersen-Bjergaard; Line S Remvig; Christian S Frandsen; Linda Hilsted; Jens Faber; Jens Juul Holst; Lise Tarnow; Jakob Skadkær Møller; Martin N Nielsen; Birger Thorsteinsson; Claus B Juhl

doi:10.1089/dia.2016.0331

Hypoglycemia-Associated EEG Changes Following Antecedent Hypoglycemia in Type 1 Diabetes Mellitus

Anne-Sophie Sejling, Troels W Kjaer, Ulrik Pedersen-Bjergaard, Line S Remvig, Christian S Frandsen, Linda Hilsted, Jens Faber, Jens Juul Holst, Lise Tarnow, Jakob Skadkær Møller, Martin N Nielsen, Birger Thorsteinsson, Claus B Juhl

Department of Clinical Medicine

10 Citations (Scopus)

Abstract

BACKGROUND: Recurrent hypoglycemia has been shown to blunt hypoglycemia symptom scores and counterregulatory hormonal responses during subsequent hypoglycemia. We therefore studied whether hypoglycemia-associated electroencephalogram (EEG) changes are affected by an antecedent episode of hypoglycemia.

METHODS: Twenty-four patients with type 1 diabetes mellitus (10 with normal hypoglycemia awareness, 14 with hypoglycemia unawareness) were studied on 2 consecutive days by hyperinsulinemic glucose clamp at hypoglycemia (2.0-2.5 mmol/L) during a 1-h period. EEG was recorded, cognitive function assessed, and hypoglycemia symptom scores and counterregulatory hormonal responses were obtained.

RESULTS: Twenty-one patients completed the study. Hypoglycemia-associated EEG changes were identified on both days with no differences in power or frequency distribution in the theta, alpha, or the combined theta-alpha band during hypoglycemia on the 2 days. Similar degree of cognitive dysfunction was also present during hypoglycemia on both days. When comparing the aware and unaware group, there were no differences in the hypoglycemia-associated EEG changes. There were very subtle differences in cognitive function between the two groups on day 2. The symptom response was higher in the aware group on both days, while only subtle differences were seen in the counterregulatory hormonal response.

CONCLUSION: Antecedent hypoglycemia does not affect hypoglycemia-associated EEG changes in patients with type 1 diabetes mellitus.

Original language	English
Journal	Diabetes Technology & Therapeutics
Volume	19
Issue number	2
Pages (from-to)	85-90
Number of pages	6
ISSN	1520-9156
DOIs	https://doi.org/10.1089/dia.2016.0331
Publication status	Published - 1 Feb 2017

Keywords

Journal Article

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1089/dia.2016.0331

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Sejling, A.-S., Kjaer, T. W., Pedersen-Bjergaard, U., Remvig, L. S., Frandsen, C. S., Hilsted, L., Faber, J., Holst, J. J., Tarnow, L., Møller, J. S., Nielsen, M. N., Thorsteinsson, B., & Juhl, C. B. (2017). Hypoglycemia-Associated EEG Changes Following Antecedent Hypoglycemia in Type 1 Diabetes Mellitus. Diabetes Technology & Therapeutics, 19(2), 85-90. https://doi.org/10.1089/dia.2016.0331

Sejling, A-S, Kjaer, TW, Pedersen-Bjergaard, U, Remvig, LS, Frandsen, CS, Hilsted, L, Faber, J, Holst, JJ, Tarnow, L, Møller, JS, Nielsen, MN, Thorsteinsson, B & Juhl, CB 2017, 'Hypoglycemia-Associated EEG Changes Following Antecedent Hypoglycemia in Type 1 Diabetes Mellitus', Diabetes Technology & Therapeutics, vol. 19, no. 2, pp. 85-90. https://doi.org/10.1089/dia.2016.0331

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AU - Sejling, Anne-Sophie

AU - Kjaer, Troels W

AU - Pedersen-Bjergaard, Ulrik

AU - Remvig, Line S

AU - Frandsen, Christian S

AU - Hilsted, Linda

AU - Faber, Jens

AU - Holst, Jens Juul

AU - Tarnow, Lise

AU - Møller, Jakob Skadkær

AU - Nielsen, Martin N

AU - Thorsteinsson, Birger

AU - Juhl, Claus B

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N2 - BACKGROUND: Recurrent hypoglycemia has been shown to blunt hypoglycemia symptom scores and counterregulatory hormonal responses during subsequent hypoglycemia. We therefore studied whether hypoglycemia-associated electroencephalogram (EEG) changes are affected by an antecedent episode of hypoglycemia.METHODS: Twenty-four patients with type 1 diabetes mellitus (10 with normal hypoglycemia awareness, 14 with hypoglycemia unawareness) were studied on 2 consecutive days by hyperinsulinemic glucose clamp at hypoglycemia (2.0-2.5 mmol/L) during a 1-h period. EEG was recorded, cognitive function assessed, and hypoglycemia symptom scores and counterregulatory hormonal responses were obtained.RESULTS: Twenty-one patients completed the study. Hypoglycemia-associated EEG changes were identified on both days with no differences in power or frequency distribution in the theta, alpha, or the combined theta-alpha band during hypoglycemia on the 2 days. Similar degree of cognitive dysfunction was also present during hypoglycemia on both days. When comparing the aware and unaware group, there were no differences in the hypoglycemia-associated EEG changes. There were very subtle differences in cognitive function between the two groups on day 2. The symptom response was higher in the aware group on both days, while only subtle differences were seen in the counterregulatory hormonal response.CONCLUSION: Antecedent hypoglycemia does not affect hypoglycemia-associated EEG changes in patients with type 1 diabetes mellitus.

AB - BACKGROUND: Recurrent hypoglycemia has been shown to blunt hypoglycemia symptom scores and counterregulatory hormonal responses during subsequent hypoglycemia. We therefore studied whether hypoglycemia-associated electroencephalogram (EEG) changes are affected by an antecedent episode of hypoglycemia.METHODS: Twenty-four patients with type 1 diabetes mellitus (10 with normal hypoglycemia awareness, 14 with hypoglycemia unawareness) were studied on 2 consecutive days by hyperinsulinemic glucose clamp at hypoglycemia (2.0-2.5 mmol/L) during a 1-h period. EEG was recorded, cognitive function assessed, and hypoglycemia symptom scores and counterregulatory hormonal responses were obtained.RESULTS: Twenty-one patients completed the study. Hypoglycemia-associated EEG changes were identified on both days with no differences in power or frequency distribution in the theta, alpha, or the combined theta-alpha band during hypoglycemia on the 2 days. Similar degree of cognitive dysfunction was also present during hypoglycemia on both days. When comparing the aware and unaware group, there were no differences in the hypoglycemia-associated EEG changes. There were very subtle differences in cognitive function between the two groups on day 2. The symptom response was higher in the aware group on both days, while only subtle differences were seen in the counterregulatory hormonal response.CONCLUSION: Antecedent hypoglycemia does not affect hypoglycemia-associated EEG changes in patients with type 1 diabetes mellitus.

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Hypoglycemia-Associated EEG Changes Following Antecedent Hypoglycemia in Type 1 Diabetes Mellitus

Abstract

Keywords

UN SDGs

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