Hyperspectral imaging in quality control of inkjet printed personalised dosage forms.

TY - JOUR

T1 - Hyperspectral imaging in quality control of inkjet printed personalised dosage forms.

AU - Vakili, Hossein

AU - Kolakovic, Ruzica

AU - Genina, Natalja

AU - Marmion, Mathieu

AU - Salo, Harri

AU - Ihalainen, Petri

AU - Peltonen, Jouko

AU - Sandler, Niklas

PY - 2015/4/15

Y1 - 2015/4/15

N2 - The aim of the study was to investigate applicability of near infra-red (NIR) hyperspectral imaging technique in quality control of printed personalised dosage forms. Inkjet printing technology was utilized to fabricate escalating doses of an active pharmaceutical ingredient (API). A solution containing anhydrous theophylline as the model drug was developed as a printable formulation. Single units solid dosage forms (SDFs) were prepared by jetting the solution onto 1cm×1cm areas on carrier substrate with multiple printing passes. It was found that the number of printing passes was in excellent correlation (R(2)=0.9994) with the amount of the dispensed drug (μgcm(-2)) based on the UV calibration plot. The API dose escalation was approximately 7.5μgcm(-2) for each printing pass concluding that inkjet printing technology can optimally provide solutions to accurate deposition of active substances with a potential for personalized dosing. Principal component analysis (PCA) was carried out in order to visualize the trends in the hyperspectral data. Subsequently, a quantitative partial least squares (PLS) regression model was created. NIR hyperspectral imaging proved (R(2)=0.9767) to be a reliable, rapid and non-destructive method to optimize quality control of these planar printed dosage forms.

AB - The aim of the study was to investigate applicability of near infra-red (NIR) hyperspectral imaging technique in quality control of printed personalised dosage forms. Inkjet printing technology was utilized to fabricate escalating doses of an active pharmaceutical ingredient (API). A solution containing anhydrous theophylline as the model drug was developed as a printable formulation. Single units solid dosage forms (SDFs) were prepared by jetting the solution onto 1cm×1cm areas on carrier substrate with multiple printing passes. It was found that the number of printing passes was in excellent correlation (R(2)=0.9994) with the amount of the dispensed drug (μgcm(-2)) based on the UV calibration plot. The API dose escalation was approximately 7.5μgcm(-2) for each printing pass concluding that inkjet printing technology can optimally provide solutions to accurate deposition of active substances with a potential for personalized dosing. Principal component analysis (PCA) was carried out in order to visualize the trends in the hyperspectral data. Subsequently, a quantitative partial least squares (PLS) regression model was created. NIR hyperspectral imaging proved (R(2)=0.9767) to be a reliable, rapid and non-destructive method to optimize quality control of these planar printed dosage forms.

KW - Cellulose carrier substrates

KW - Ethanol (PubChem CID: 702)

KW - Glycerol (PubChem CID: 753

KW - Inkjet printing

KW - Multivariate analysis

KW - Near infrared hyperspectral imaging

KW - Personalized medicine

KW - Quality control

KW - Theophylline (PubChem CID: 2153)

U2 - 10.1016/j.ijpharm.2014.12.034

DO - 10.1016/j.ijpharm.2014.12.034

M3 - Journal article

C2 - 25527212

SN - 0378-5173

VL - 483

SP - 244

EP - 249

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

IS - 1-2

ER -