TY - JOUR
T1 - Hyperspectral imaging in quality control of inkjet printed personalised dosage forms.
AU - Vakili, Hossein
AU - Kolakovic, Ruzica
AU - Genina, Natalja
AU - Marmion, Mathieu
AU - Salo, Harri
AU - Ihalainen, Petri
AU - Peltonen, Jouko
AU - Sandler, Niklas
PY - 2015/4/15
Y1 - 2015/4/15
N2 - The aim of the study was to investigate applicability of near infra-red (NIR) hyperspectral imaging technique in quality control of printed personalised dosage forms. Inkjet printing technology was utilized to fabricate escalating doses of an active pharmaceutical ingredient (API). A solution containing anhydrous theophylline as the model drug was developed as a printable formulation. Single units solid dosage forms (SDFs) were prepared by jetting the solution onto 1cm×1cm areas on carrier substrate with multiple printing passes. It was found that the number of printing passes was in excellent correlation (R(2)=0.9994) with the amount of the dispensed drug (μgcm(-2)) based on the UV calibration plot. The API dose escalation was approximately 7.5μgcm(-2) for each printing pass concluding that inkjet printing technology can optimally provide solutions to accurate deposition of active substances with a potential for personalized dosing. Principal component analysis (PCA) was carried out in order to visualize the trends in the hyperspectral data. Subsequently, a quantitative partial least squares (PLS) regression model was created. NIR hyperspectral imaging proved (R(2)=0.9767) to be a reliable, rapid and non-destructive method to optimize quality control of these planar printed dosage forms.
AB - The aim of the study was to investigate applicability of near infra-red (NIR) hyperspectral imaging technique in quality control of printed personalised dosage forms. Inkjet printing technology was utilized to fabricate escalating doses of an active pharmaceutical ingredient (API). A solution containing anhydrous theophylline as the model drug was developed as a printable formulation. Single units solid dosage forms (SDFs) were prepared by jetting the solution onto 1cm×1cm areas on carrier substrate with multiple printing passes. It was found that the number of printing passes was in excellent correlation (R(2)=0.9994) with the amount of the dispensed drug (μgcm(-2)) based on the UV calibration plot. The API dose escalation was approximately 7.5μgcm(-2) for each printing pass concluding that inkjet printing technology can optimally provide solutions to accurate deposition of active substances with a potential for personalized dosing. Principal component analysis (PCA) was carried out in order to visualize the trends in the hyperspectral data. Subsequently, a quantitative partial least squares (PLS) regression model was created. NIR hyperspectral imaging proved (R(2)=0.9767) to be a reliable, rapid and non-destructive method to optimize quality control of these planar printed dosage forms.
KW - Cellulose carrier substrates
KW - Ethanol (PubChem CID: 702)
KW - Glycerol (PubChem CID: 753
KW - Inkjet printing
KW - Multivariate analysis
KW - Near infrared hyperspectral imaging
KW - Personalized medicine
KW - Quality control
KW - Theophylline (PubChem CID: 2153)
U2 - 10.1016/j.ijpharm.2014.12.034
DO - 10.1016/j.ijpharm.2014.12.034
M3 - Journal article
C2 - 25527212
SN - 0378-5173
VL - 483
SP - 244
EP - 249
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
IS - 1-2
ER -