Abstract
The need for experimental models is obvious. In animal models it is possible to study vascular responses, neurogenic inflammation, c-fos expression etc. However, the pathophysiology of migraine remains unsolved, why results from animal studies not directly can be related to the migraine attack, which is a human experience. A set-up for investigations of experimental headache and migraine in humans, has been evaluated and headache mechanisms explored by using nitroglycerin and other headache-inducing agents. Nitric oxide (NO) or other parts of the NO activated cascade seems to be responsible for the induced headache and migraine. Perspectives are discussed.
| Original language | English |
|---|---|
| Journal | Cephalalgia : an international journal of headache |
| Volume | 21 |
| Issue number | 7 |
| Pages (from-to) | 781-5 |
| Number of pages | 5 |
| ISSN | 0333-1024 |
| Publication status | Published - Sept 2001 |
Keywords
- Animals
- Cerebrovascular Circulation
- Humans
- Migraine Disorders
- Models, Neurological
- Nitroglycerin
- Vasodilator Agents