Abstract
The need for experimental models is obvious. In animal models it is possible to study vascular responses, neurogenic inflammation, c-fos expression etc. However, the pathophysiology of migraine remains unsolved, why results from animal studies not directly can be related to the migraine attack, which is a human experience. A set-up for investigations of experimental headache and migraine in humans, has been evaluated and headache mechanisms explored by using nitroglycerin and other headache-inducing agents. Nitric oxide (NO) or other parts of the NO activated cascade seems to be responsible for the induced headache and migraine. Perspectives are discussed.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Cephalalgia : an international journal of headache |
| Vol/bind | 21 |
| Udgave nummer | 7 |
| Sider (fra-til) | 781-5 |
| Antal sider | 5 |
| ISSN | 0333-1024 |
| Status | Udgivet - sep. 2001 |