How vitamin A metabolizing dendritic cells are generated in the gut mucosa

William Agace; Emma K Persson

doi:10.1016/j.it.2011.10.001

How vitamin A metabolizing dendritic cells are generated in the gut mucosa

William Agace, Emma K Persson

Department of Immunology and Microbiology

68 Citations (Scopus)

Abstract

CD103 ⁺ dendritic cells (DCs) represent the major migratory DC population in the intestinal lamina propria and are believed to play an essential role in the initiation and regulation of mucosal adaptive immune responses. Small intestine (SI) CD103 ⁺ DCs have an enhanced capacity to generate the vitamin A metabolite, retinoic acid, a property that underlies their ability to induce the gut homing receptors CC chemokine receptor 9 and α4β7 on responding T and B cells, and enhance forkhead box P3 ⁺ T regulatory and IgA plasma cell differentiation in vitro. In this review, we discuss the environmental signals that appear to promote vitamin A metabolising activity in SI CD103 ⁺ DCs in the steady state and thus which may contribute to driving the unique nature of SI immune responses.

Original language	English
Journal	Trends in Immunology
Volume	33
Issue number	1
Pages (from-to)	42-48
Number of pages	7
ISSN	1471-4906
DOIs	https://doi.org/10.1016/j.it.2011.10.001
Publication status	Published - Jan 2012

Keywords

Antigens, CD
Dendritic Cells
Humans
Integrin alpha Chains
Intestinal Mucosa
Toll-Like Receptors
Vitamin A

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10.1016/j.it.2011.10.001

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abstract = "CD103 + dendritic cells (DCs) represent the major migratory DC population in the intestinal lamina propria and are believed to play an essential role in the initiation and regulation of mucosal adaptive immune responses. Small intestine (SI) CD103 + DCs have an enhanced capacity to generate the vitamin A metabolite, retinoic acid, a property that underlies their ability to induce the gut homing receptors CC chemokine receptor 9 and α4β7 on responding T and B cells, and enhance forkhead box P3 + T regulatory and IgA plasma cell differentiation in vitro. In this review, we discuss the environmental signals that appear to promote vitamin A metabolising activity in SI CD103 + DCs in the steady state and thus which may contribute to driving the unique nature of SI immune responses.",

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AU - Persson, Emma K

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AB - CD103 + dendritic cells (DCs) represent the major migratory DC population in the intestinal lamina propria and are believed to play an essential role in the initiation and regulation of mucosal adaptive immune responses. Small intestine (SI) CD103 + DCs have an enhanced capacity to generate the vitamin A metabolite, retinoic acid, a property that underlies their ability to induce the gut homing receptors CC chemokine receptor 9 and α4β7 on responding T and B cells, and enhance forkhead box P3 + T regulatory and IgA plasma cell differentiation in vitro. In this review, we discuss the environmental signals that appear to promote vitamin A metabolising activity in SI CD103 + DCs in the steady state and thus which may contribute to driving the unique nature of SI immune responses.

KW - Antigens, CD

KW - Dendritic Cells

KW - Humans

KW - Integrin alpha Chains

KW - Intestinal Mucosa

KW - Toll-Like Receptors

KW - Vitamin A

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DO - 10.1016/j.it.2011.10.001

M3 - Journal article

C2 - 22079120

SN - 1471-4906

VL - 33

SP - 42

EP - 48

JO - Trends in Immunology

JF - Trends in Immunology

IS - 1

ER -

How vitamin A metabolizing dendritic cells are generated in the gut mucosa

Abstract

Keywords

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