How vitamin A metabolizing dendritic cells are generated in the gut mucosa

William Agace; Emma K Persson

doi:10.1016/j.it.2011.10.001

How vitamin A metabolizing dendritic cells are generated in the gut mucosa

William Agace, Emma K Persson

LUKKET: Institut for Immunologi og Mikrobiologi

68 Citationer (Scopus)

Abstract

CD103 ⁺ dendritic cells (DCs) represent the major migratory DC population in the intestinal lamina propria and are believed to play an essential role in the initiation and regulation of mucosal adaptive immune responses. Small intestine (SI) CD103 ⁺ DCs have an enhanced capacity to generate the vitamin A metabolite, retinoic acid, a property that underlies their ability to induce the gut homing receptors CC chemokine receptor 9 and α4β7 on responding T and B cells, and enhance forkhead box P3 ⁺ T regulatory and IgA plasma cell differentiation in vitro. In this review, we discuss the environmental signals that appear to promote vitamin A metabolising activity in SI CD103 ⁺ DCs in the steady state and thus which may contribute to driving the unique nature of SI immune responses.

Originalsprog	Engelsk
Tidsskrift	Trends in Immunology
Vol/bind	33
Udgave nummer	1
Sider (fra-til)	42-48
Antal sider	7
ISSN	1471-4906
DOI	https://doi.org/10.1016/j.it.2011.10.001
Status	Udgivet - jan. 2012

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10.1016/j.it.2011.10.001

Citationsformater

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title = "How vitamin A metabolizing dendritic cells are generated in the gut mucosa",

abstract = "CD103 + dendritic cells (DCs) represent the major migratory DC population in the intestinal lamina propria and are believed to play an essential role in the initiation and regulation of mucosal adaptive immune responses. Small intestine (SI) CD103 + DCs have an enhanced capacity to generate the vitamin A metabolite, retinoic acid, a property that underlies their ability to induce the gut homing receptors CC chemokine receptor 9 and α4β7 on responding T and B cells, and enhance forkhead box P3 + T regulatory and IgA plasma cell differentiation in vitro. In this review, we discuss the environmental signals that appear to promote vitamin A metabolising activity in SI CD103 + DCs in the steady state and thus which may contribute to driving the unique nature of SI immune responses.",

keywords = "Antigens, CD, Dendritic Cells, Humans, Integrin alpha Chains, Intestinal Mucosa, Toll-Like Receptors, Vitamin A",

author = "William Agace and Persson, {Emma K}",

year = "2012",

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doi = "10.1016/j.it.2011.10.001",

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T1 - How vitamin A metabolizing dendritic cells are generated in the gut mucosa

AU - Agace, William

AU - Persson, Emma K

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N2 - CD103 + dendritic cells (DCs) represent the major migratory DC population in the intestinal lamina propria and are believed to play an essential role in the initiation and regulation of mucosal adaptive immune responses. Small intestine (SI) CD103 + DCs have an enhanced capacity to generate the vitamin A metabolite, retinoic acid, a property that underlies their ability to induce the gut homing receptors CC chemokine receptor 9 and α4β7 on responding T and B cells, and enhance forkhead box P3 + T regulatory and IgA plasma cell differentiation in vitro. In this review, we discuss the environmental signals that appear to promote vitamin A metabolising activity in SI CD103 + DCs in the steady state and thus which may contribute to driving the unique nature of SI immune responses.

AB - CD103 + dendritic cells (DCs) represent the major migratory DC population in the intestinal lamina propria and are believed to play an essential role in the initiation and regulation of mucosal adaptive immune responses. Small intestine (SI) CD103 + DCs have an enhanced capacity to generate the vitamin A metabolite, retinoic acid, a property that underlies their ability to induce the gut homing receptors CC chemokine receptor 9 and α4β7 on responding T and B cells, and enhance forkhead box P3 + T regulatory and IgA plasma cell differentiation in vitro. In this review, we discuss the environmental signals that appear to promote vitamin A metabolising activity in SI CD103 + DCs in the steady state and thus which may contribute to driving the unique nature of SI immune responses.

KW - Antigens, CD

KW - Dendritic Cells

KW - Humans

KW - Integrin alpha Chains

KW - Intestinal Mucosa

KW - Toll-Like Receptors

KW - Vitamin A

U2 - 10.1016/j.it.2011.10.001

DO - 10.1016/j.it.2011.10.001

M3 - Journal article

C2 - 22079120

SN - 1471-4906

VL - 33

SP - 42

EP - 48

JO - Trends in Immunology

JF - Trends in Immunology

IS - 1

ER -

How vitamin A metabolizing dendritic cells are generated in the gut mucosa

Abstract

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