How the sequence of a gene can tune its translation

Kurt Fredrick, Michael Ibba

111 Citations (Scopus)

Abstract

Sixty-one codons specify 20 amino acids, offering cells many options for encoding a polypeptide sequence. Two new studies (Cannarrozzi et al., 2010; Tuller et al., 2010) now foster the idea that patterns of codon usage can control ribosome speed, fine-tuning translation to increase the efficiency of protein synthesis.
Original languageEnglish
JournalCell
Volume141
Issue number2
Pages (from-to)227-9
Number of pages3
ISSN0092-8674
DOIs
Publication statusPublished - 16 Apr 2010

Keywords

  • Base Sequence
  • Codon
  • Protein Biosynthesis
  • Ribosomes

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