How the sequence of a gene can tune its translation

TY - JOUR

T1 - How the sequence of a gene can tune its translation

AU - Fredrick, Kurt

AU - Ibba, Michael

N1 - Copyright 2010 Elsevier Inc. All rights reserved.

PY - 2010/4/16

Y1 - 2010/4/16

N2 - Sixty-one codons specify 20 amino acids, offering cells many options for encoding a polypeptide sequence. Two new studies (Cannarrozzi et al., 2010; Tuller et al., 2010) now foster the idea that patterns of codon usage can control ribosome speed, fine-tuning translation to increase the efficiency of protein synthesis.

AB - Sixty-one codons specify 20 amino acids, offering cells many options for encoding a polypeptide sequence. Two new studies (Cannarrozzi et al., 2010; Tuller et al., 2010) now foster the idea that patterns of codon usage can control ribosome speed, fine-tuning translation to increase the efficiency of protein synthesis.

KW - Base Sequence

KW - Codon

KW - Protein Biosynthesis

KW - Ribosomes

U2 - 10.1016/j.cell.2010.03.033

DO - 10.1016/j.cell.2010.03.033

M3 - Review

C2 - 20403320

SN - 0092-8674

VL - 141

SP - 227

EP - 229

JO - Cell

JF - Cell

IS - 2

ER -