HLA-DP antigens are involved in the susceptibility to multiple sclerosis

Niels Ødum; J J Hyldig-Nielsen; N Morling; M Sandberg-Wollheim; P Platz; A Svejgaard

HLA-DP antigens are involved in the susceptibility to multiple sclerosis

Niels Ødum, J J Hyldig-Nielsen, N Morling, M Sandberg-Wollheim, P Platz, A Svejgaard

62 Citations (Scopus)

Abstract

Forty-five unrelated patients with multiple sclerosis (MS) from Sweden and 166 Danish controls were typed for HLA-DP using Primed Lymphocyte Typing. Thirty-nine MS-patients and 63 controls were also DNA-typed with the Restriction Fragment Length Polymorphism (RFLP) technique for HLA-DP and -DR genes. The frequencies of DPw4 were 93.3% in MS patients and 72.3% in controls (relative risk, RR = 5.4, p = 0.0014). The DR2 antigen was present in 75.5% of the patients and in 33.7% of the controls (RR = 6.1, p less than 10(-6)). DPw4 was not associated (i.e., was not in linkage disequilibrium) with DR2 in patients or controls. Thus, in MS the associations with DP and DR are independent of each other. However, the combined presence of DPw4 and DR2 gave a significantly higher risk than each antigen alone, indicating that synergism between DP and DR gene products may play a role in the genetic susceptibility to MS.

Original language	English
Journal	HLA
Volume	31
Issue number	5
Pages (from-to)	235-7
Number of pages	2
ISSN	2059-2302
Publication status	Published - 1988

Cite this

@article{0e1e02c0fda211ddb219000ea68e967b,

title = "HLA-DP antigens are involved in the susceptibility to multiple sclerosis",

abstract = "Forty-five unrelated patients with multiple sclerosis (MS) from Sweden and 166 Danish controls were typed for HLA-DP using Primed Lymphocyte Typing. Thirty-nine MS-patients and 63 controls were also DNA-typed with the Restriction Fragment Length Polymorphism (RFLP) technique for HLA-DP and -DR genes. The frequencies of DPw4 were 93.3% in MS patients and 72.3% in controls (relative risk, RR = 5.4, p = 0.0014). The DR2 antigen was present in 75.5% of the patients and in 33.7% of the controls (RR = 6.1, p less than 10(-6)). DPw4 was not associated (i.e., was not in linkage disequilibrium) with DR2 in patients or controls. Thus, in MS the associations with DP and DR are independent of each other. However, the combined presence of DPw4 and DR2 gave a significantly higher risk than each antigen alone, indicating that synergism between DP and DR gene products may play a role in the genetic susceptibility to MS.",

author = "Niels {\O}dum and Hyldig-Nielsen, {J J} and N Morling and M Sandberg-Wollheim and P Platz and A Svejgaard",

note = "Keywords: HLA-D Antigens; HLA-DP Antigens; HLA-DR Antigens; Humans; Multiple Sclerosis",

year = "1988",

language = "English",

volume = "31",

pages = "235--7",

journal = "HLA",

issn = "2059-2302",

publisher = "Wiley",

number = "5",

}

TY - JOUR

T1 - HLA-DP antigens are involved in the susceptibility to multiple sclerosis

AU - Ødum, Niels

AU - Hyldig-Nielsen, J J

AU - Morling, N

AU - Sandberg-Wollheim, M

AU - Platz, P

AU - Svejgaard, A

N1 - Keywords: HLA-D Antigens; HLA-DP Antigens; HLA-DR Antigens; Humans; Multiple Sclerosis

PY - 1988

Y1 - 1988

N2 - Forty-five unrelated patients with multiple sclerosis (MS) from Sweden and 166 Danish controls were typed for HLA-DP using Primed Lymphocyte Typing. Thirty-nine MS-patients and 63 controls were also DNA-typed with the Restriction Fragment Length Polymorphism (RFLP) technique for HLA-DP and -DR genes. The frequencies of DPw4 were 93.3% in MS patients and 72.3% in controls (relative risk, RR = 5.4, p = 0.0014). The DR2 antigen was present in 75.5% of the patients and in 33.7% of the controls (RR = 6.1, p less than 10(-6)). DPw4 was not associated (i.e., was not in linkage disequilibrium) with DR2 in patients or controls. Thus, in MS the associations with DP and DR are independent of each other. However, the combined presence of DPw4 and DR2 gave a significantly higher risk than each antigen alone, indicating that synergism between DP and DR gene products may play a role in the genetic susceptibility to MS.

AB - Forty-five unrelated patients with multiple sclerosis (MS) from Sweden and 166 Danish controls were typed for HLA-DP using Primed Lymphocyte Typing. Thirty-nine MS-patients and 63 controls were also DNA-typed with the Restriction Fragment Length Polymorphism (RFLP) technique for HLA-DP and -DR genes. The frequencies of DPw4 were 93.3% in MS patients and 72.3% in controls (relative risk, RR = 5.4, p = 0.0014). The DR2 antigen was present in 75.5% of the patients and in 33.7% of the controls (RR = 6.1, p less than 10(-6)). DPw4 was not associated (i.e., was not in linkage disequilibrium) with DR2 in patients or controls. Thus, in MS the associations with DP and DR are independent of each other. However, the combined presence of DPw4 and DR2 gave a significantly higher risk than each antigen alone, indicating that synergism between DP and DR gene products may play a role in the genetic susceptibility to MS.

M3 - Journal article

C2 - 3400089

SN - 2059-2302

VL - 31

SP - 235

EP - 237

JO - HLA

JF - HLA

IS - 5

ER -

HLA-DP antigens are involved in the susceptibility to multiple sclerosis

Abstract

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