Hjertepåvirkning fra 5-fluorouracil og capecitabin

Søren Astrup Jensen; Lene Bæksgaard Jensen; Lone Nørgaard Petersen; Lars Reiter; Jens Benn Sørensen

Hjertepåvirkning fra 5-fluorouracil og capecitabin

Translated title of the contribution: [Cardiotoxicity induced by 5-fluorouracil or capecitabine]

Søren Astrup Jensen, Lene Bæksgaard Jensen, Lone Nørgaard Petersen, Lars Reiter, Jens Benn Sørensen

Abstract

5-fluorouracil and capecitabine have significant antineoplastic activity towards various solid tumors. Cardiotoxicity causing angina, arythmia and infarction are serious adverse events associated with these agents. The pathogenesis is discussed and symptoms of cardiotoxicity, intervention with nitroglycerine and risk factors as cardiac comorbidity are described. Following cardiotoxicity, lack of alternative active agents may provide grounds to rechallenge with 5-FU. In this situation, dose-modified 5-FU-based chemotherapy supported by medical antiangina prevention is feasible.

Translated title of the contribution	[Cardiotoxicity induced by 5-fluorouracil or capecitabine]
Original language	Danish
Journal	Ugeskrift for Laeger
Volume	172
Issue number	1
Pages (from-to)	48-51
Number of pages	4
ISSN	0041-5782
Publication status	Published - 4 Jan 2010

Cite this

@article{bc3bf26386ef46a087bf25d2b7d7e503,

title = "Hjertep{\aa}virkning fra 5-fluorouracil og capecitabin",

abstract = "5-fluorouracil and capecitabine have significant antineoplastic activity towards various solid tumors. Cardiotoxicity causing angina, arythmia and infarction are serious adverse events associated with these agents. The pathogenesis is discussed and symptoms of cardiotoxicity, intervention with nitroglycerine and risk factors as cardiac comorbidity are described. Following cardiotoxicity, lack of alternative active agents may provide grounds to rechallenge with 5-FU. In this situation, dose-modified 5-FU-based chemotherapy supported by medical antiangina prevention is feasible.",

author = "Jensen, {S{\o}ren Astrup} and Jensen, {Lene B{\ae}ksgaard} and Petersen, {Lone N{\o}rgaard} and Lars Reiter and S{\o}rensen, {Jens Benn}",

year = "2010",

month = jan,

day = "4",

language = "Dansk",

volume = "172",

pages = "48--51",

journal = "Ugeskrift for Laeger",

issn = "0041-5782",

publisher = "Almindelige Danske Laegeforening",

number = "1",

}

TY - JOUR

T1 - Hjertepåvirkning fra 5-fluorouracil og capecitabin

AU - Jensen, Søren Astrup

AU - Jensen, Lene Bæksgaard

AU - Petersen, Lone Nørgaard

AU - Reiter, Lars

AU - Sørensen, Jens Benn

PY - 2010/1/4

Y1 - 2010/1/4

N2 - 5-fluorouracil and capecitabine have significant antineoplastic activity towards various solid tumors. Cardiotoxicity causing angina, arythmia and infarction are serious adverse events associated with these agents. The pathogenesis is discussed and symptoms of cardiotoxicity, intervention with nitroglycerine and risk factors as cardiac comorbidity are described. Following cardiotoxicity, lack of alternative active agents may provide grounds to rechallenge with 5-FU. In this situation, dose-modified 5-FU-based chemotherapy supported by medical antiangina prevention is feasible.

AB - 5-fluorouracil and capecitabine have significant antineoplastic activity towards various solid tumors. Cardiotoxicity causing angina, arythmia and infarction are serious adverse events associated with these agents. The pathogenesis is discussed and symptoms of cardiotoxicity, intervention with nitroglycerine and risk factors as cardiac comorbidity are described. Following cardiotoxicity, lack of alternative active agents may provide grounds to rechallenge with 5-FU. In this situation, dose-modified 5-FU-based chemotherapy supported by medical antiangina prevention is feasible.

M3 - Tidsskriftartikel

SN - 0041-5782

VL - 172

SP - 48

EP - 51

JO - Ugeskrift for Laeger

JF - Ugeskrift for Laeger

IS - 1

ER -

Hjertepåvirkning fra 5-fluorouracil og capecitabin

Abstract

Fingerprint

Cite this