Hjertepåvirkning fra 5-fluorouracil og capecitabin

Søren Astrup Jensen; Lene Bæksgaard Jensen; Lone Nørgaard Petersen; Lars Reiter; Jens Benn Sørensen

Hjertepåvirkning fra 5-fluorouracil og capecitabin

Søren Astrup Jensen, Lene Bæksgaard Jensen, Lone Nørgaard Petersen, Lars Reiter, Jens Benn Sørensen

Abstract

5-fluorouracil and capecitabine have significant antineoplastic activity towards various solid tumors. Cardiotoxicity causing angina, arythmia and infarction are serious adverse events associated with these agents. The pathogenesis is discussed and symptoms of cardiotoxicity, intervention with nitroglycerine and risk factors as cardiac comorbidity are described. Following cardiotoxicity, lack of alternative active agents may provide grounds to rechallenge with 5-FU. In this situation, dose-modified 5-FU-based chemotherapy supported by medical antiangina prevention is feasible.

Bidragets oversatte titel	[Cardiotoxicity induced by 5-fluorouracil or capecitabine]
Originalsprog	Dansk
Tidsskrift	Ugeskrift for Laeger
Vol/bind	172
Udgave nummer	1
Sider (fra-til)	48-51
Antal sider	4
ISSN	0041-5782
Status	Udgivet - 4 jan. 2010

Citationsformater

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abstract = "5-fluorouracil and capecitabine have significant antineoplastic activity towards various solid tumors. Cardiotoxicity causing angina, arythmia and infarction are serious adverse events associated with these agents. The pathogenesis is discussed and symptoms of cardiotoxicity, intervention with nitroglycerine and risk factors as cardiac comorbidity are described. Following cardiotoxicity, lack of alternative active agents may provide grounds to rechallenge with 5-FU. In this situation, dose-modified 5-FU-based chemotherapy supported by medical antiangina prevention is feasible.",

author = "Jensen, {S{\o}ren Astrup} and Jensen, {Lene B{\ae}ksgaard} and Petersen, {Lone N{\o}rgaard} and Lars Reiter and S{\o}rensen, {Jens Benn}",

year = "2010",

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language = "Dansk",

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T1 - Hjertepåvirkning fra 5-fluorouracil og capecitabin

AU - Jensen, Søren Astrup

AU - Jensen, Lene Bæksgaard

AU - Petersen, Lone Nørgaard

AU - Reiter, Lars

AU - Sørensen, Jens Benn

PY - 2010/1/4

Y1 - 2010/1/4

N2 - 5-fluorouracil and capecitabine have significant antineoplastic activity towards various solid tumors. Cardiotoxicity causing angina, arythmia and infarction are serious adverse events associated with these agents. The pathogenesis is discussed and symptoms of cardiotoxicity, intervention with nitroglycerine and risk factors as cardiac comorbidity are described. Following cardiotoxicity, lack of alternative active agents may provide grounds to rechallenge with 5-FU. In this situation, dose-modified 5-FU-based chemotherapy supported by medical antiangina prevention is feasible.

AB - 5-fluorouracil and capecitabine have significant antineoplastic activity towards various solid tumors. Cardiotoxicity causing angina, arythmia and infarction are serious adverse events associated with these agents. The pathogenesis is discussed and symptoms of cardiotoxicity, intervention with nitroglycerine and risk factors as cardiac comorbidity are described. Following cardiotoxicity, lack of alternative active agents may provide grounds to rechallenge with 5-FU. In this situation, dose-modified 5-FU-based chemotherapy supported by medical antiangina prevention is feasible.

M3 - Tidsskriftartikel

SN - 0041-5782

VL - 172

SP - 48

EP - 51

JO - Ugeskrift for Laeger

JF - Ugeskrift for Laeger

IS - 1

ER -

Hjertepåvirkning fra 5-fluorouracil og capecitabin

Abstract

Fingeraftryk

Citationsformater