Histone demethylases in development and disease

Marianne Terndrup Pedersen; Kristian Helin

doi:10.1016/j.tcb.2010.08.011

Histone demethylases in development and disease

Marianne Terndrup Pedersen, Kristian Helin

249 Citations (Scopus)

Abstract

Histone modifications serve as regulatory marks that are instrumental for the control of transcription and chromatin architecture. Strict regulation of gene expression patterns is crucial during development and differentiation, where diverse cell types evolve from common predecessors. Since the first histone lysine demethylase was discovered in 2004, a number of demethylases have been identified and implicated in the control of gene expression programmes and cell fate decisions. Histone demethylases are now emerging as important players in developmental processes and have been linked to human diseases such as neurological disorders and cancer.

Original language	English
Journal	Trends in Cell Biology
Volume	20
Issue number	11
Pages (from-to)	662-71
Number of pages	10
ISSN	0962-8924
DOIs	https://doi.org/10.1016/j.tcb.2010.08.011
Publication status	Published - 1 Nov 2010

Keywords

Animals
Gene Expression Regulation
Histone Demethylases
Humans
Mammals
Neoplasms
Nervous System Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tcb.2010.08.011

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AB - Histone modifications serve as regulatory marks that are instrumental for the control of transcription and chromatin architecture. Strict regulation of gene expression patterns is crucial during development and differentiation, where diverse cell types evolve from common predecessors. Since the first histone lysine demethylase was discovered in 2004, a number of demethylases have been identified and implicated in the control of gene expression programmes and cell fate decisions. Histone demethylases are now emerging as important players in developmental processes and have been linked to human diseases such as neurological disorders and cancer.

KW - Animals

KW - Gene Expression Regulation

KW - Histone Demethylases

KW - Humans

KW - Mammals

KW - Neoplasms

KW - Nervous System Diseases

U2 - 10.1016/j.tcb.2010.08.011

DO - 10.1016/j.tcb.2010.08.011

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SP - 662

EP - 671

JO - Trends in Cell Biology

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ER -

Histone demethylases in development and disease

Abstract

Keywords

UN SDGs

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