Histone demethylases in development and disease

TY - JOUR

T1 - Histone demethylases in development and disease

AU - Pedersen, Marianne Terndrup

AU - Helin, Kristian

N1 - Copyright © 2010 Elsevier Ltd. All rights reserved.

PY - 2010/11/1

Y1 - 2010/11/1

N2 - Histone modifications serve as regulatory marks that are instrumental for the control of transcription and chromatin architecture. Strict regulation of gene expression patterns is crucial during development and differentiation, where diverse cell types evolve from common predecessors. Since the first histone lysine demethylase was discovered in 2004, a number of demethylases have been identified and implicated in the control of gene expression programmes and cell fate decisions. Histone demethylases are now emerging as important players in developmental processes and have been linked to human diseases such as neurological disorders and cancer.

AB - Histone modifications serve as regulatory marks that are instrumental for the control of transcription and chromatin architecture. Strict regulation of gene expression patterns is crucial during development and differentiation, where diverse cell types evolve from common predecessors. Since the first histone lysine demethylase was discovered in 2004, a number of demethylases have been identified and implicated in the control of gene expression programmes and cell fate decisions. Histone demethylases are now emerging as important players in developmental processes and have been linked to human diseases such as neurological disorders and cancer.

KW - Animals

KW - Gene Expression Regulation

KW - Histone Demethylases

KW - Humans

KW - Mammals

KW - Neoplasms

KW - Nervous System Diseases

U2 - 10.1016/j.tcb.2010.08.011

DO - 10.1016/j.tcb.2010.08.011

M3 - Journal article

C2 - 20863703

SN - 0962-8924

VL - 20

SP - 662

EP - 671

JO - Trends in Cell Biology

JF - Trends in Cell Biology

IS - 11

ER -