Higher protein intake is not associated with decreased kidney function in pre-diabetic older adults following a one-year intervention: A PREVIEW sub-study

Grith Møller; Jens Rikardt Andersen; Christian Ritz; Marta P Silvestre; Santiago Navas-Carretero; Elli Jalo; Pia Christensen; Elizabeth M Simpson; Moira A Taylor; J Alfredo Martinez; Ian Macdonald; Nils Swindell; Kelly Mackintosh; Gareth Stratton; Mikael Fogelholm; Thomas Meinert Larsen; Sally D Poppitt; Lars Ove Dragsted; Anne Raben

doi:10.3390/nu10010054

Higher protein intake is not associated with decreased kidney function in pre-diabetic older adults following a one-year intervention: A PREVIEW sub-study

Grith Møller, Jens Rikardt Andersen, Christian Ritz, Marta P Silvestre, Santiago Navas-Carretero, Elli Jalo, Pia Christensen, Elizabeth M Simpson, Moira A Taylor, J Alfredo Martinez, Ian Macdonald, Nils Swindell, Kelly Mackintosh, Gareth Stratton, Mikael Fogelholm, Thomas Meinert Larsen, Sally D Poppitt, Lars Ove Dragsted, Anne Raben

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Abstract

Concerns about detrimental renal effects of a high-protein intake have been raised due to an induced glomerular hyperfiltration, since this may accelerate the progression of kidney disease. The aim of this sub-study was to assess the effect of a higher intake of protein on kidney function in pre-diabetic men and women, aged 55 years and older. Analyses were based on baseline and one-year
data in a sub-group of 310 participants included in the PREVIEW project (PREVention of diabetes through lifestyle Intervention and population studies in Europe and around the World). Protein intake was estimated from four-day dietary records and 24-hour urinary urea excretion. We used linear regression to assess the association between protein intake after one year of intervention and
kidney function markers: creatinine clearance, estimated glomerular filtration rate (eGFR), urinary albumin/creatinine ratio (ACR), urinary urea/creatinine ratio (UCR), serum creatinine, and serum urea before and after adjustments for potential confounders. A higher protein intake was associated with a significant increase in UCR (p = 0.03) and serum urea (p = 0.05) after one year. There were
no associations between increased protein intake and creatinine clearance, eGFR, ACR, or serum creatinine. We found no indication of impaired kidney function after one year with a higher protein intake in pre-diabetic older adults.

Original language	English
Article number	54
Journal	Nutrients
Volume	54
Number of pages	11
ISSN	2072-6643
DOIs	https://doi.org/10.3390/nu10010054
Publication status	Published - 9 Jan 2018

Keywords

Faculty of Science
Pre-diabetes
Dietary protein
Creatinine clearance
Glomerular filtration rate
Albumin
Urea

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Møller et al_Nutrients_2018_Vol 10_00054Final published version, 276 KBLicence: CC BY

Cite this

Møller, G., Andersen, J. R., Ritz, C., Silvestre, M. P., Navas-Carretero, S., Jalo, E., Christensen, P., Simpson, E. M., Taylor, M. A., Martinez, J. A., Macdonald, I., Swindell, N., Mackintosh, K., Stratton, G., Fogelholm, M., Larsen, T. M., Poppitt, S. D., Dragsted, L. O., & Raben, A. (2018). Higher protein intake is not associated with decreased kidney function in pre-diabetic older adults following a one-year intervention: A PREVIEW sub-study. Nutrients, 54, Article 54. https://doi.org/10.3390/nu10010054

Møller, G, Andersen, JR, Ritz, C, Silvestre, MP, Navas-Carretero, S, Jalo, E, Christensen, P, Simpson, EM, Taylor, MA, Martinez, JA, Macdonald, I, Swindell, N, Mackintosh, K, Stratton, G, Fogelholm, M, Larsen, TM, Poppitt, SD, Dragsted, LO & Raben, A 2018, 'Higher protein intake is not associated with decreased kidney function in pre-diabetic older adults following a one-year intervention: A PREVIEW sub-study', Nutrients, vol. 54, 54. https://doi.org/10.3390/nu10010054

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abstract = "Concerns about detrimental renal effects of a high-protein intake have been raised due to an induced glomerular hyperfiltration, since this may accelerate the progression of kidney disease. The aim of this sub-study was to assess the effect of a higher intake of protein on kidney function in pre-diabetic men and women, aged 55 years and older. Analyses were based on baseline and one-yeardata in a sub-group of 310 participants included in the PREVIEW project (PREVention of diabetes through lifestyle Intervention and population studies in Europe and around the World). Protein intake was estimated from four-day dietary records and 24-hour urinary urea excretion. We used linear regression to assess the association between protein intake after one year of intervention andkidney function markers: creatinine clearance, estimated glomerular filtration rate (eGFR), urinary albumin/creatinine ratio (ACR), urinary urea/creatinine ratio (UCR), serum creatinine, and serum urea before and after adjustments for potential confounders. A higher protein intake was associated with a significant increase in UCR (p = 0.03) and serum urea (p = 0.05) after one year. There wereno associations between increased protein intake and creatinine clearance, eGFR, ACR, or serum creatinine. We found no indication of impaired kidney function after one year with a higher protein intake in pre-diabetic older adults.",

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AU - Ritz, Christian

AU - Silvestre, Marta P

AU - Navas-Carretero, Santiago

AU - Jalo, Elli

AU - Christensen, Pia

AU - Simpson, Elizabeth M

AU - Taylor, Moira A

AU - Martinez, J Alfredo

AU - Macdonald, Ian

AU - Swindell, Nils

AU - Mackintosh, Kelly

AU - Stratton, Gareth

AU - Fogelholm, Mikael

AU - Larsen, Thomas Meinert

AU - Poppitt, Sally D

AU - Dragsted, Lars Ove

AU - Raben, Anne

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N2 - Concerns about detrimental renal effects of a high-protein intake have been raised due to an induced glomerular hyperfiltration, since this may accelerate the progression of kidney disease. The aim of this sub-study was to assess the effect of a higher intake of protein on kidney function in pre-diabetic men and women, aged 55 years and older. Analyses were based on baseline and one-yeardata in a sub-group of 310 participants included in the PREVIEW project (PREVention of diabetes through lifestyle Intervention and population studies in Europe and around the World). Protein intake was estimated from four-day dietary records and 24-hour urinary urea excretion. We used linear regression to assess the association between protein intake after one year of intervention andkidney function markers: creatinine clearance, estimated glomerular filtration rate (eGFR), urinary albumin/creatinine ratio (ACR), urinary urea/creatinine ratio (UCR), serum creatinine, and serum urea before and after adjustments for potential confounders. A higher protein intake was associated with a significant increase in UCR (p = 0.03) and serum urea (p = 0.05) after one year. There wereno associations between increased protein intake and creatinine clearance, eGFR, ACR, or serum creatinine. We found no indication of impaired kidney function after one year with a higher protein intake in pre-diabetic older adults.

AB - Concerns about detrimental renal effects of a high-protein intake have been raised due to an induced glomerular hyperfiltration, since this may accelerate the progression of kidney disease. The aim of this sub-study was to assess the effect of a higher intake of protein on kidney function in pre-diabetic men and women, aged 55 years and older. Analyses were based on baseline and one-yeardata in a sub-group of 310 participants included in the PREVIEW project (PREVention of diabetes through lifestyle Intervention and population studies in Europe and around the World). Protein intake was estimated from four-day dietary records and 24-hour urinary urea excretion. We used linear regression to assess the association between protein intake after one year of intervention andkidney function markers: creatinine clearance, estimated glomerular filtration rate (eGFR), urinary albumin/creatinine ratio (ACR), urinary urea/creatinine ratio (UCR), serum creatinine, and serum urea before and after adjustments for potential confounders. A higher protein intake was associated with a significant increase in UCR (p = 0.03) and serum urea (p = 0.05) after one year. There wereno associations between increased protein intake and creatinine clearance, eGFR, ACR, or serum creatinine. We found no indication of impaired kidney function after one year with a higher protein intake in pre-diabetic older adults.

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KW - Pre-diabetes

KW - Dietary protein

KW - Creatinine clearance

KW - Glomerular filtration rate

KW - Albumin

KW - Urea

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DO - 10.3390/nu10010054

M3 - Journal article

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SN - 2072-6643

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JO - Nutrients

JF - Nutrients

M1 - 54

ER -

Higher protein intake is not associated with decreased kidney function in pre-diabetic older adults following a one-year intervention: A PREVIEW sub-study

Abstract

Keywords

UN SDGs

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