Higher protein intake is not associated with decreased kidney function in pre-diabetic older adults following a one-year intervention: A PREVIEW sub-study

Grith Møller; Jens Rikardt Andersen; Christian Ritz; Marta P Silvestre; Santiago Navas-Carretero; Elli Jalo; Pia Christensen; Elizabeth M Simpson; Moira A Taylor; J Alfredo Martinez; Ian Macdonald; Nils Swindell; Kelly Mackintosh; Gareth Stratton; Mikael Fogelholm; Thomas Meinert Larsen; Sally D Poppitt; Lars Ove Dragsted; Anne Raben

doi:10.3390/nu10010054

Higher protein intake is not associated with decreased kidney function in pre-diabetic older adults following a one-year intervention: A PREVIEW sub-study

Grith Møller, Jens Rikardt Andersen, Christian Ritz, Marta P Silvestre, Santiago Navas-Carretero, Elli Jalo, Pia Christensen, Elizabeth M Simpson, Moira A Taylor, J Alfredo Martinez, Ian Macdonald, Nils Swindell, Kelly Mackintosh, Gareth Stratton, Mikael Fogelholm, Thomas Meinert Larsen, Sally D Poppitt, Lars Ove Dragsted, Anne Raben

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Abstract

Concerns about detrimental renal effects of a high-protein intake have been raised due to an induced glomerular hyperfiltration, since this may accelerate the progression of kidney disease. The aim of this sub-study was to assess the effect of a higher intake of protein on kidney function in pre-diabetic men and women, aged 55 years and older. Analyses were based on baseline and one-year
data in a sub-group of 310 participants included in the PREVIEW project (PREVention of diabetes through lifestyle Intervention and population studies in Europe and around the World). Protein intake was estimated from four-day dietary records and 24-hour urinary urea excretion. We used linear regression to assess the association between protein intake after one year of intervention and
kidney function markers: creatinine clearance, estimated glomerular filtration rate (eGFR), urinary albumin/creatinine ratio (ACR), urinary urea/creatinine ratio (UCR), serum creatinine, and serum urea before and after adjustments for potential confounders. A higher protein intake was associated with a significant increase in UCR (p = 0.03) and serum urea (p = 0.05) after one year. There were
no associations between increased protein intake and creatinine clearance, eGFR, ACR, or serum creatinine. We found no indication of impaired kidney function after one year with a higher protein intake in pre-diabetic older adults.

Originalsprog	Engelsk
Artikelnummer	54
Tidsskrift	Nutrients
Vol/bind	54
Antal sider	11
ISSN	2072-6643
DOI	https://doi.org/10.3390/nu10010054
Status	Udgivet - 9 jan. 2018

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10.3390/nu10010054Licens: CC BY

Møller et al_Nutrients_2018_Vol 10_00054Forlagets udgivne version, 276 KBLicens: CC BY

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Møller, G., Andersen, J. R., Ritz, C., Silvestre, M. P., Navas-Carretero, S., Jalo, E., Christensen, P., Simpson, E. M., Taylor, M. A., Martinez, J. A., Macdonald, I., Swindell, N., Mackintosh, K., Stratton, G., Fogelholm, M., Larsen, T. M., Poppitt, S. D., Dragsted, L. O., & Raben, A. (2018). Higher protein intake is not associated with decreased kidney function in pre-diabetic older adults following a one-year intervention: A PREVIEW sub-study. Nutrients, 54, Artikel 54. https://doi.org/10.3390/nu10010054

Møller, G, Andersen, JR, Ritz, C, Silvestre, MP, Navas-Carretero, S, Jalo, E, Christensen, P, Simpson, EM, Taylor, MA, Martinez, JA, Macdonald, I, Swindell, N, Mackintosh, K, Stratton, G, Fogelholm, M, Larsen, TM, Poppitt, SD, Dragsted, LO & Raben, A 2018, 'Higher protein intake is not associated with decreased kidney function in pre-diabetic older adults following a one-year intervention: A PREVIEW sub-study', Nutrients, bind 54, 54. https://doi.org/10.3390/nu10010054

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title = "Higher protein intake is not associated with decreased kidney function in pre-diabetic older adults following a one-year intervention: A PREVIEW sub-study",

abstract = "Concerns about detrimental renal effects of a high-protein intake have been raised due to an induced glomerular hyperfiltration, since this may accelerate the progression of kidney disease. The aim of this sub-study was to assess the effect of a higher intake of protein on kidney function in pre-diabetic men and women, aged 55 years and older. Analyses were based on baseline and one-yeardata in a sub-group of 310 participants included in the PREVIEW project (PREVention of diabetes through lifestyle Intervention and population studies in Europe and around the World). Protein intake was estimated from four-day dietary records and 24-hour urinary urea excretion. We used linear regression to assess the association between protein intake after one year of intervention andkidney function markers: creatinine clearance, estimated glomerular filtration rate (eGFR), urinary albumin/creatinine ratio (ACR), urinary urea/creatinine ratio (UCR), serum creatinine, and serum urea before and after adjustments for potential confounders. A higher protein intake was associated with a significant increase in UCR (p = 0.03) and serum urea (p = 0.05) after one year. There wereno associations between increased protein intake and creatinine clearance, eGFR, ACR, or serum creatinine. We found no indication of impaired kidney function after one year with a higher protein intake in pre-diabetic older adults.",

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author = "Grith M{\o}ller and Andersen, {Jens Rikardt} and Christian Ritz and Silvestre, {Marta P} and Santiago Navas-Carretero and Elli Jalo and Pia Christensen and Simpson, {Elizabeth M} and Taylor, {Moira A} and Martinez, {J Alfredo} and Ian Macdonald and Nils Swindell and Kelly Mackintosh and Gareth Stratton and Mikael Fogelholm and Larsen, {Thomas Meinert} and Poppitt, {Sally D} and Dragsted, {Lars Ove} and Anne Raben",

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T2 - A PREVIEW sub-study

AU - Møller, Grith

AU - Andersen, Jens Rikardt

AU - Ritz, Christian

AU - Silvestre, Marta P

AU - Navas-Carretero, Santiago

AU - Jalo, Elli

AU - Christensen, Pia

AU - Simpson, Elizabeth M

AU - Taylor, Moira A

AU - Martinez, J Alfredo

AU - Macdonald, Ian

AU - Swindell, Nils

AU - Mackintosh, Kelly

AU - Stratton, Gareth

AU - Fogelholm, Mikael

AU - Larsen, Thomas Meinert

AU - Poppitt, Sally D

AU - Dragsted, Lars Ove

AU - Raben, Anne

N1 - CURIS 2018 NEXS 021

PY - 2018/1/9

Y1 - 2018/1/9

N2 - Concerns about detrimental renal effects of a high-protein intake have been raised due to an induced glomerular hyperfiltration, since this may accelerate the progression of kidney disease. The aim of this sub-study was to assess the effect of a higher intake of protein on kidney function in pre-diabetic men and women, aged 55 years and older. Analyses were based on baseline and one-yeardata in a sub-group of 310 participants included in the PREVIEW project (PREVention of diabetes through lifestyle Intervention and population studies in Europe and around the World). Protein intake was estimated from four-day dietary records and 24-hour urinary urea excretion. We used linear regression to assess the association between protein intake after one year of intervention andkidney function markers: creatinine clearance, estimated glomerular filtration rate (eGFR), urinary albumin/creatinine ratio (ACR), urinary urea/creatinine ratio (UCR), serum creatinine, and serum urea before and after adjustments for potential confounders. A higher protein intake was associated with a significant increase in UCR (p = 0.03) and serum urea (p = 0.05) after one year. There wereno associations between increased protein intake and creatinine clearance, eGFR, ACR, or serum creatinine. We found no indication of impaired kidney function after one year with a higher protein intake in pre-diabetic older adults.

AB - Concerns about detrimental renal effects of a high-protein intake have been raised due to an induced glomerular hyperfiltration, since this may accelerate the progression of kidney disease. The aim of this sub-study was to assess the effect of a higher intake of protein on kidney function in pre-diabetic men and women, aged 55 years and older. Analyses were based on baseline and one-yeardata in a sub-group of 310 participants included in the PREVIEW project (PREVention of diabetes through lifestyle Intervention and population studies in Europe and around the World). Protein intake was estimated from four-day dietary records and 24-hour urinary urea excretion. We used linear regression to assess the association between protein intake after one year of intervention andkidney function markers: creatinine clearance, estimated glomerular filtration rate (eGFR), urinary albumin/creatinine ratio (ACR), urinary urea/creatinine ratio (UCR), serum creatinine, and serum urea before and after adjustments for potential confounders. A higher protein intake was associated with a significant increase in UCR (p = 0.03) and serum urea (p = 0.05) after one year. There wereno associations between increased protein intake and creatinine clearance, eGFR, ACR, or serum creatinine. We found no indication of impaired kidney function after one year with a higher protein intake in pre-diabetic older adults.

KW - Faculty of Science

KW - Pre-diabetes

KW - Dietary protein

KW - Creatinine clearance

KW - Glomerular filtration rate

KW - Albumin

KW - Urea

U2 - 10.3390/nu10010054

DO - 10.3390/nu10010054

M3 - Journal article

C2 - 29315212

SN - 2072-6643

VL - 54

JO - Nutrients

JF - Nutrients

M1 - 54

ER -

Higher protein intake is not associated with decreased kidney function in pre-diabetic older adults following a one-year intervention: A PREVIEW sub-study

Abstract

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