High levels of fetal DNA are associated with increased risk of spontaneous preterm delivery

Tanja R Jakobsen; Frederik B Clausen; Line Rode; Morten Hanefeld Dziegiel; Ann Tabor

doi:10.1002/pd.3917

High levels of fetal DNA are associated with increased risk of spontaneous preterm delivery

Tanja R Jakobsen, Frederik B Clausen, Line Rode, Morten Hanefeld Dziegiel, Ann Tabor

52 Citations (Scopus)

Abstract

Objective: To assess whether spontaneous preterm delivery can be predicted from the amount of cell free fetal DNA (cffDNA) as determined by routine fetal RHD genotyping at 25weeks' gestation. Study design: Cohort study including RhD negative women participating in a routine RHD screening programme. A standard dilution curve was used to quantify the amounts of cffDNA. Values above the 95^th centile for the study population defined high levels of cffDNA. Results: We found a highly significant association between preterm delivery and cffDNA levels above the 95^th centile (p=0.002). Using logistic regression, women with high levels of cffDNA had an odds ratio of 6.3 (95% confidence interval: 1.9-20.9) for preterm delivery before 37 weeks and an odds ratio for delivery before 34weeks of 16.6 (95% confidence interval: 3.2-84.7) when adjusting for gestational age at sampling, body mass index and previous miscarriages/terminations of pregnancy. Conclusion: High levels of cffDNA at 25weeks are associated with increased risk of spontaneous preterm delivery.

Original language	English
Journal	Journal of Prenatal Diagnosis and Therapy
Volume	32
Issue number	9
Pages (from-to)	840-5
Number of pages	6
ISSN	0976-1756
DOIs	https://doi.org/10.1002/pd.3917
Publication status	Published - Sept 2012

Keywords

Adult
Case-Control Studies
DNA
Delivery, Obstetric
Female
Fetal Membranes, Premature Rupture
Fetus
Gestational Age
Humans
Mothers
Obstetric Labor, Premature
Pregnancy
Pregnancy Trimester, Second
Premature Birth
Risk Factors

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title = "High levels of fetal DNA are associated with increased risk of spontaneous preterm delivery",

abstract = "Objective: To assess whether spontaneous preterm delivery can be predicted from the amount of cell free fetal DNA (cffDNA) as determined by routine fetal RHD genotyping at 25weeks' gestation. Study design: Cohort study including RhD negative women participating in a routine RHD screening programme. A standard dilution curve was used to quantify the amounts of cffDNA. Values above the 95th centile for the study population defined high levels of cffDNA. Results: We found a highly significant association between preterm delivery and cffDNA levels above the 95th centile (p=0.002). Using logistic regression, women with high levels of cffDNA had an odds ratio of 6.3 (95% confidence interval: 1.9-20.9) for preterm delivery before 37 weeks and an odds ratio for delivery before 34weeks of 16.6 (95% confidence interval: 3.2-84.7) when adjusting for gestational age at sampling, body mass index and previous miscarriages/terminations of pregnancy. Conclusion: High levels of cffDNA at 25weeks are associated with increased risk of spontaneous preterm delivery.",

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author = "Jakobsen, {Tanja R} and Clausen, {Frederik B} and Line Rode and Dziegiel, {Morten Hanefeld} and Ann Tabor",

note = "{\textcopyright} 2012 John Wiley & Sons, Ltd.",

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T1 - High levels of fetal DNA are associated with increased risk of spontaneous preterm delivery

AU - Jakobsen, Tanja R

AU - Clausen, Frederik B

AU - Rode, Line

AU - Dziegiel, Morten Hanefeld

AU - Tabor, Ann

PY - 2012/9

Y1 - 2012/9

N2 - Objective: To assess whether spontaneous preterm delivery can be predicted from the amount of cell free fetal DNA (cffDNA) as determined by routine fetal RHD genotyping at 25weeks' gestation. Study design: Cohort study including RhD negative women participating in a routine RHD screening programme. A standard dilution curve was used to quantify the amounts of cffDNA. Values above the 95th centile for the study population defined high levels of cffDNA. Results: We found a highly significant association between preterm delivery and cffDNA levels above the 95th centile (p=0.002). Using logistic regression, women with high levels of cffDNA had an odds ratio of 6.3 (95% confidence interval: 1.9-20.9) for preterm delivery before 37 weeks and an odds ratio for delivery before 34weeks of 16.6 (95% confidence interval: 3.2-84.7) when adjusting for gestational age at sampling, body mass index and previous miscarriages/terminations of pregnancy. Conclusion: High levels of cffDNA at 25weeks are associated with increased risk of spontaneous preterm delivery.

AB - Objective: To assess whether spontaneous preterm delivery can be predicted from the amount of cell free fetal DNA (cffDNA) as determined by routine fetal RHD genotyping at 25weeks' gestation. Study design: Cohort study including RhD negative women participating in a routine RHD screening programme. A standard dilution curve was used to quantify the amounts of cffDNA. Values above the 95th centile for the study population defined high levels of cffDNA. Results: We found a highly significant association between preterm delivery and cffDNA levels above the 95th centile (p=0.002). Using logistic regression, women with high levels of cffDNA had an odds ratio of 6.3 (95% confidence interval: 1.9-20.9) for preterm delivery before 37 weeks and an odds ratio for delivery before 34weeks of 16.6 (95% confidence interval: 3.2-84.7) when adjusting for gestational age at sampling, body mass index and previous miscarriages/terminations of pregnancy. Conclusion: High levels of cffDNA at 25weeks are associated with increased risk of spontaneous preterm delivery.

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KW - Delivery, Obstetric

KW - Female

KW - Fetal Membranes, Premature Rupture

KW - Fetus

KW - Gestational Age

KW - Humans

KW - Mothers

KW - Obstetric Labor, Premature

KW - Pregnancy

KW - Pregnancy Trimester, Second

KW - Premature Birth

KW - Risk Factors

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DO - 10.1002/pd.3917

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JO - Journal of Prenatal Diagnosis and Therapy

JF - Journal of Prenatal Diagnosis and Therapy

IS - 9

ER -

High levels of fetal DNA are associated with increased risk of spontaneous preterm delivery

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Keywords

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