Abstract
Objective: To assess whether spontaneous preterm delivery can be predicted from the amount of cell free fetal DNA (cffDNA) as determined by routine fetal RHD genotyping at 25weeks' gestation. Study design: Cohort study including RhD negative women participating in a routine RHD screening programme. A standard dilution curve was used to quantify the amounts of cffDNA. Values above the 95th centile for the study population defined high levels of cffDNA. Results: We found a highly significant association between preterm delivery and cffDNA levels above the 95th centile (p=0.002). Using logistic regression, women with high levels of cffDNA had an odds ratio of 6.3 (95% confidence interval: 1.9-20.9) for preterm delivery before 37 weeks and an odds ratio for delivery before 34weeks of 16.6 (95% confidence interval: 3.2-84.7) when adjusting for gestational age at sampling, body mass index and previous miscarriages/terminations of pregnancy. Conclusion: High levels of cffDNA at 25weeks are associated with increased risk of spontaneous preterm delivery.
| Original language | English |
|---|---|
| Journal | Journal of Prenatal Diagnosis and Therapy |
| Volume | 32 |
| Issue number | 9 |
| Pages (from-to) | 840-5 |
| Number of pages | 6 |
| ISSN | 0976-1756 |
| DOIs | |
| Publication status | Published - Sept 2012 |
Keywords
- Adult
- Case-Control Studies
- DNA
- Delivery, Obstetric
- Female
- Fetal Membranes, Premature Rupture
- Fetus
- Gestational Age
- Humans
- Mothers
- Obstetric Labor, Premature
- Pregnancy
- Pregnancy Trimester, Second
- Premature Birth
- Risk Factors