High levels of fetal DNA are associated with increased risk of spontaneous preterm delivery

TY - JOUR

T1 - High levels of fetal DNA are associated with increased risk of spontaneous preterm delivery

AU - Jakobsen, Tanja R

AU - Clausen, Frederik B

AU - Rode, Line

AU - Dziegiel, Morten Hanefeld

AU - Tabor, Ann

N1 - © 2012 John Wiley & Sons, Ltd.

PY - 2012/9

Y1 - 2012/9

N2 - Objective: To assess whether spontaneous preterm delivery can be predicted from the amount of cell free fetal DNA (cffDNA) as determined by routine fetal RHD genotyping at 25weeks' gestation. Study design: Cohort study including RhD negative women participating in a routine RHD screening programme. A standard dilution curve was used to quantify the amounts of cffDNA. Values above the 95th centile for the study population defined high levels of cffDNA. Results: We found a highly significant association between preterm delivery and cffDNA levels above the 95th centile (p=0.002). Using logistic regression, women with high levels of cffDNA had an odds ratio of 6.3 (95% confidence interval: 1.9-20.9) for preterm delivery before 37 weeks and an odds ratio for delivery before 34weeks of 16.6 (95% confidence interval: 3.2-84.7) when adjusting for gestational age at sampling, body mass index and previous miscarriages/terminations of pregnancy. Conclusion: High levels of cffDNA at 25weeks are associated with increased risk of spontaneous preterm delivery.

AB - Objective: To assess whether spontaneous preterm delivery can be predicted from the amount of cell free fetal DNA (cffDNA) as determined by routine fetal RHD genotyping at 25weeks' gestation. Study design: Cohort study including RhD negative women participating in a routine RHD screening programme. A standard dilution curve was used to quantify the amounts of cffDNA. Values above the 95th centile for the study population defined high levels of cffDNA. Results: We found a highly significant association between preterm delivery and cffDNA levels above the 95th centile (p=0.002). Using logistic regression, women with high levels of cffDNA had an odds ratio of 6.3 (95% confidence interval: 1.9-20.9) for preterm delivery before 37 weeks and an odds ratio for delivery before 34weeks of 16.6 (95% confidence interval: 3.2-84.7) when adjusting for gestational age at sampling, body mass index and previous miscarriages/terminations of pregnancy. Conclusion: High levels of cffDNA at 25weeks are associated with increased risk of spontaneous preterm delivery.

KW - Adult

KW - Case-Control Studies

KW - DNA

KW - Delivery, Obstetric

KW - Female

KW - Fetal Membranes, Premature Rupture

KW - Fetus

KW - Gestational Age

KW - Humans

KW - Mothers

KW - Obstetric Labor, Premature

KW - Pregnancy

KW - Pregnancy Trimester, Second

KW - Premature Birth

KW - Risk Factors

U2 - 10.1002/pd.3917

DO - 10.1002/pd.3917

M3 - Journal article

C2 - 22711432

SN - 0976-1756

VL - 32

SP - 840

EP - 845

JO - Journal of Prenatal Diagnosis and Therapy

JF - Journal of Prenatal Diagnosis and Therapy

IS - 9

ER -