High-fat feeding induces mobilization of vitamin C in obese prone rats

B. Tranberg; L. I. Hellgren; J. Lykkesfeldt; A. K. Hansen

doi:10.1016/j.rvsc.2018.06.011

High-fat feeding induces mobilization of vitamin C in obese prone rats

B. Tranberg, L. I. Hellgren, J. Lykkesfeldt, A. K. Hansen^*

^*Corresponding author for this work

Lifepharm

Abstract

In obesity and dyslipidemia, hydrolysis of triacylglycerol (TAG) into non-esterified fatty acids (NEFAs) may contribute to insulin resistance, and production of oxygenated, bioactive polyunsaturated fatty acids may increase oxidative stress. Here we show that after six weeks of high-fat feeding of obese prone rats (Crl:OP(CD), vitamin C was increased both in liver (P < 0.01) and plasma (P < 0.001), while both TAG (P < 0.01) and NEFA (P < 0.001) were lower than in low-fat fed control rats. Hepatic vitamin C biosynthesis was similar between groups, indicating that a new steady state level was established with a higher vitamin C level adequate for supplying the systemic needs. Glucose and insulin sensitivity were unaffected at this stage. Eventually, the mobilization of vitamin C may be seen as a mechanism to protect the host against insulin resistance.

Original language	English
Journal	Research in Veterinary Science
Volume	119
Pages (from-to)	167-169
Number of pages	3
ISSN	0034-5288
DOIs	https://doi.org/10.1016/j.rvsc.2018.06.011
Publication status	Published - 2018

Keywords

High-fat diet
Insulin resistance
Obesity
Rat
Vitamin C

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.rvsc.2018.06.011

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title = "High-fat feeding induces mobilization of vitamin C in obese prone rats",

abstract = "In obesity and dyslipidemia, hydrolysis of triacylglycerol (TAG) into non-esterified fatty acids (NEFAs) may contribute to insulin resistance, and production of oxygenated, bioactive polyunsaturated fatty acids may increase oxidative stress. Here we show that after six weeks of high-fat feeding of obese prone rats (Crl:OP(CD), vitamin C was increased both in liver (P < 0.01) and plasma (P < 0.001), while both TAG (P < 0.01) and NEFA (P < 0.001) were lower than in low-fat fed control rats. Hepatic vitamin C biosynthesis was similar between groups, indicating that a new steady state level was established with a higher vitamin C level adequate for supplying the systemic needs. Glucose and insulin sensitivity were unaffected at this stage. Eventually, the mobilization of vitamin C may be seen as a mechanism to protect the host against insulin resistance.",

keywords = "High-fat diet, Insulin resistance, Obesity, Rat, Vitamin C",

author = "B. Tranberg and Hellgren, {L. I.} and J. Lykkesfeldt and Hansen, {A. K.}",

year = "2018",

doi = "10.1016/j.rvsc.2018.06.011",

language = "English",

volume = "119",

pages = "167--169",

journal = "Research in Veterinary Science",

issn = "0034-5288",

publisher = "Elsevier",

}

TY - JOUR

T1 - High-fat feeding induces mobilization of vitamin C in obese prone rats

AU - Tranberg, B.

AU - Hellgren, L. I.

AU - Lykkesfeldt, J.

AU - Hansen, A. K.

PY - 2018

Y1 - 2018

N2 - In obesity and dyslipidemia, hydrolysis of triacylglycerol (TAG) into non-esterified fatty acids (NEFAs) may contribute to insulin resistance, and production of oxygenated, bioactive polyunsaturated fatty acids may increase oxidative stress. Here we show that after six weeks of high-fat feeding of obese prone rats (Crl:OP(CD), vitamin C was increased both in liver (P < 0.01) and plasma (P < 0.001), while both TAG (P < 0.01) and NEFA (P < 0.001) were lower than in low-fat fed control rats. Hepatic vitamin C biosynthesis was similar between groups, indicating that a new steady state level was established with a higher vitamin C level adequate for supplying the systemic needs. Glucose and insulin sensitivity were unaffected at this stage. Eventually, the mobilization of vitamin C may be seen as a mechanism to protect the host against insulin resistance.

AB - In obesity and dyslipidemia, hydrolysis of triacylglycerol (TAG) into non-esterified fatty acids (NEFAs) may contribute to insulin resistance, and production of oxygenated, bioactive polyunsaturated fatty acids may increase oxidative stress. Here we show that after six weeks of high-fat feeding of obese prone rats (Crl:OP(CD), vitamin C was increased both in liver (P < 0.01) and plasma (P < 0.001), while both TAG (P < 0.01) and NEFA (P < 0.001) were lower than in low-fat fed control rats. Hepatic vitamin C biosynthesis was similar between groups, indicating that a new steady state level was established with a higher vitamin C level adequate for supplying the systemic needs. Glucose and insulin sensitivity were unaffected at this stage. Eventually, the mobilization of vitamin C may be seen as a mechanism to protect the host against insulin resistance.

KW - High-fat diet

KW - Insulin resistance

KW - Obesity

KW - Rat

KW - Vitamin C

U2 - 10.1016/j.rvsc.2018.06.011

DO - 10.1016/j.rvsc.2018.06.011

M3 - Journal article

C2 - 29945036

AN - SCOPUS:85048853890

SN - 0034-5288

VL - 119

SP - 167

EP - 169

JO - Research in Veterinary Science

JF - Research in Veterinary Science

ER -

High-fat feeding induces mobilization of vitamin C in obese prone rats

Abstract

Keywords

UN SDGs

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