Hepatic Insulin Clearance in Regulation of Systemic Insulin Concentrations—Role of Carbohydrate and Energy Availability

TY - JOUR

T1 - Hepatic Insulin Clearance in Regulation of Systemic Insulin Concentrations—Role of Carbohydrate and Energy Availability

AU - Bojsen-Møller, Kirstine N

AU - Lundsgaard, Anne-Marie

AU - Madsbad, Sten

AU - Kiens, Bente

AU - Holst, Jens Juul

N1 - CURIS 2018 NEXS 368

PY - 2018/11

Y1 - 2018/11

N2 - Hyperinsulinemia is the hallmark of insulin resistance in obesity, and the relative importance of insulin clearance, insulin resistance, and insulin hypersecretion has been widely debated. On the basis of recent experimental evidence, we summarize existing evidence to suggest hepatic insulin clearance as a major and immediate regulator of systemic insulin concentrations responding within days to altered dietary energy and, in particular, carbohydrate intake. Hepatic insulin clearance seems to be closely associated with opposite alterations in hepatic lipid content and glucose production, providing a potential mechanistic link to hepatic insulin sensitivity. The molecular regulation of insulin clearance in the liver is likely to involve changes in insulin binding and receptor internalization in response to the dietary alterations, the molecular mechanisms of which await further research.

AB - Hyperinsulinemia is the hallmark of insulin resistance in obesity, and the relative importance of insulin clearance, insulin resistance, and insulin hypersecretion has been widely debated. On the basis of recent experimental evidence, we summarize existing evidence to suggest hepatic insulin clearance as a major and immediate regulator of systemic insulin concentrations responding within days to altered dietary energy and, in particular, carbohydrate intake. Hepatic insulin clearance seems to be closely associated with opposite alterations in hepatic lipid content and glucose production, providing a potential mechanistic link to hepatic insulin sensitivity. The molecular regulation of insulin clearance in the liver is likely to involve changes in insulin binding and receptor internalization in response to the dietary alterations, the molecular mechanisms of which await further research.

KW - Animals

KW - Carbohydrate Metabolism/physiology

KW - Energy Metabolism/physiology

KW - Humans

KW - Insulin/blood

KW - Liver/metabolism

U2 - 10.2337/db18-0539

DO - 10.2337/db18-0539

M3 - Journal article

C2 - 30348819

AN - SCOPUS:85055143689

SN - 0012-1797

VL - 67

SP - 2129

EP - 2136

JO - Diabetes

JF - Diabetes

IS - 11

ER -