Headache and prolonged dilatation of the middle meningeal artery by PACAP38 in healthy volunteers

Faisal Mohammad Amin; Mohammad Sohail Asghar; Song Guo; Anders Hougaard; Adam Espe Hansen; Henrik Winther Schytz; Rob J van der Geest; Patrick Jh de Koning; Henrik Bw Larsson; Jes Olesen; Messoud Ashina

doi:10.1177/0333102411431333

Headache and prolonged dilatation of the middle meningeal artery by PACAP38 in healthy volunteers

Faisal Mohammad Amin, Mohammad Sohail Asghar, Song Guo, Anders Hougaard, Adam Espe Hansen, Henrik Winther Schytz, Rob J van der Geest, Patrick Jh de Koning, Henrik Bw Larsson, Jes Olesen, Messoud Ashina

73 Citations (Scopus)

Abstract

Aim: To explore a possible relationship between vasodilatation and delayed headache we examined the effect of pituitary adenylate cyclase-activating polypeptide-38 (PACAP38) on the middle meningeal artery (MMA) and middle cerebral artery (MCA) using high resolution magnetic resonance angiography (MRA).Methods: In a double-blind, randomized, placebo-controlled study 14 healthy volunteers were scanned repeatedly after infusion (20 min) of 10 pmol/kg/min PACAP38 or placebo. In addition, four participants were scanned following subcutaneous sumatriptan (6 mg).Results: We found significant dilatation of the MMA (p = 0.00001), but not of the MCA (p = 0.50) after PACAP38. There was no change after placebo (p > 0.40). Vasodilatation (range 16-23%) lasted more than 5 h. Sumatriptan selectively contracted the MMA by 12.3% (p = 0.043).Conclusion: PACAP38-induced headache is associated with prolonged dilatation of the MMA but not of the MCA. Sumatriptan relieves headache in parallel with contraction of the MMA but not of the MCA.

Original language	English
Journal	Cephalalgia
Volume	32
Issue number	2
Pages (from-to)	140-9
Number of pages	10
ISSN	0333-1024
DOIs	https://doi.org/10.1177/0333102411431333
Publication status	Published - Jan 2012

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@article{e49d6ef19ad64ca8b491411059c85abb,

title = "Headache and prolonged dilatation of the middle meningeal artery by PACAP38 in healthy volunteers",

abstract = "Aim: To explore a possible relationship between vasodilatation and delayed headache we examined the effect of pituitary adenylate cyclase-activating polypeptide-38 (PACAP38) on the middle meningeal artery (MMA) and middle cerebral artery (MCA) using high resolution magnetic resonance angiography (MRA).Methods: In a double-blind, randomized, placebo-controlled study 14 healthy volunteers were scanned repeatedly after infusion (20 min) of 10 pmol/kg/min PACAP38 or placebo. In addition, four participants were scanned following subcutaneous sumatriptan (6 mg).Results: We found significant dilatation of the MMA (p = 0.00001), but not of the MCA (p = 0.50) after PACAP38. There was no change after placebo (p > 0.40). Vasodilatation (range 16-23%) lasted more than 5 h. Sumatriptan selectively contracted the MMA by 12.3% (p = 0.043).Conclusion: PACAP38-induced headache is associated with prolonged dilatation of the MMA but not of the MCA. Sumatriptan relieves headache in parallel with contraction of the MMA but not of the MCA.",

author = "Amin, {Faisal Mohammad} and Asghar, {Mohammad Sohail} and Song Guo and Anders Hougaard and Hansen, {Adam Espe} and Schytz, {Henrik Winther} and {van der Geest}, {Rob J} and {de Koning}, {Patrick Jh} and Larsson, {Henrik Bw} and Jes Olesen and Messoud Ashina",

year = "2012",

month = jan,

doi = "10.1177/0333102411431333",

language = "English",

volume = "32",

pages = "140--9",

journal = "Cephalalgia, Supplement",

issn = "0800-1952",

publisher = "SAGE Publications",

number = "2",

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T1 - Headache and prolonged dilatation of the middle meningeal artery by PACAP38 in healthy volunteers

AU - Amin, Faisal Mohammad

AU - Asghar, Mohammad Sohail

AU - Guo, Song

AU - Hougaard, Anders

AU - Hansen, Adam Espe

AU - Schytz, Henrik Winther

AU - van der Geest, Rob J

AU - de Koning, Patrick Jh

AU - Larsson, Henrik Bw

AU - Olesen, Jes

AU - Ashina, Messoud

PY - 2012/1

Y1 - 2012/1

N2 - Aim: To explore a possible relationship between vasodilatation and delayed headache we examined the effect of pituitary adenylate cyclase-activating polypeptide-38 (PACAP38) on the middle meningeal artery (MMA) and middle cerebral artery (MCA) using high resolution magnetic resonance angiography (MRA).Methods: In a double-blind, randomized, placebo-controlled study 14 healthy volunteers were scanned repeatedly after infusion (20 min) of 10 pmol/kg/min PACAP38 or placebo. In addition, four participants were scanned following subcutaneous sumatriptan (6 mg).Results: We found significant dilatation of the MMA (p = 0.00001), but not of the MCA (p = 0.50) after PACAP38. There was no change after placebo (p > 0.40). Vasodilatation (range 16-23%) lasted more than 5 h. Sumatriptan selectively contracted the MMA by 12.3% (p = 0.043).Conclusion: PACAP38-induced headache is associated with prolonged dilatation of the MMA but not of the MCA. Sumatriptan relieves headache in parallel with contraction of the MMA but not of the MCA.

AB - Aim: To explore a possible relationship between vasodilatation and delayed headache we examined the effect of pituitary adenylate cyclase-activating polypeptide-38 (PACAP38) on the middle meningeal artery (MMA) and middle cerebral artery (MCA) using high resolution magnetic resonance angiography (MRA).Methods: In a double-blind, randomized, placebo-controlled study 14 healthy volunteers were scanned repeatedly after infusion (20 min) of 10 pmol/kg/min PACAP38 or placebo. In addition, four participants were scanned following subcutaneous sumatriptan (6 mg).Results: We found significant dilatation of the MMA (p = 0.00001), but not of the MCA (p = 0.50) after PACAP38. There was no change after placebo (p > 0.40). Vasodilatation (range 16-23%) lasted more than 5 h. Sumatriptan selectively contracted the MMA by 12.3% (p = 0.043).Conclusion: PACAP38-induced headache is associated with prolonged dilatation of the MMA but not of the MCA. Sumatriptan relieves headache in parallel with contraction of the MMA but not of the MCA.

U2 - 10.1177/0333102411431333

DO - 10.1177/0333102411431333

M3 - Journal article

C2 - 22174350

SN - 0800-1952

VL - 32

SP - 140

EP - 149

JO - Cephalalgia, Supplement

JF - Cephalalgia, Supplement

IS - 2

ER -

Headache and prolonged dilatation of the middle meningeal artery by PACAP38 in healthy volunteers

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