TY - JOUR
T1 - Headache and prolonged dilatation of the middle meningeal artery by PACAP38 in healthy volunteers
AU - Amin, Faisal Mohammad
AU - Asghar, Mohammad Sohail
AU - Guo, Song
AU - Hougaard, Anders
AU - Hansen, Adam Espe
AU - Schytz, Henrik Winther
AU - van der Geest, Rob J
AU - de Koning, Patrick Jh
AU - Larsson, Henrik Bw
AU - Olesen, Jes
AU - Ashina, Messoud
PY - 2012/1
Y1 - 2012/1
N2 - Aim: To explore a possible relationship between vasodilatation and delayed headache we examined the effect of pituitary adenylate cyclase-activating polypeptide-38 (PACAP38) on the middle meningeal artery (MMA) and middle cerebral artery (MCA) using high resolution magnetic resonance angiography (MRA).Methods: In a double-blind, randomized, placebo-controlled study 14 healthy volunteers were scanned repeatedly after infusion (20 min) of 10 pmol/kg/min PACAP38 or placebo. In addition, four participants were scanned following subcutaneous sumatriptan (6 mg).Results: We found significant dilatation of the MMA (p = 0.00001), but not of the MCA (p = 0.50) after PACAP38. There was no change after placebo (p > 0.40). Vasodilatation (range 16-23%) lasted more than 5 h. Sumatriptan selectively contracted the MMA by 12.3% (p = 0.043).Conclusion: PACAP38-induced headache is associated with prolonged dilatation of the MMA but not of the MCA. Sumatriptan relieves headache in parallel with contraction of the MMA but not of the MCA.
AB - Aim: To explore a possible relationship between vasodilatation and delayed headache we examined the effect of pituitary adenylate cyclase-activating polypeptide-38 (PACAP38) on the middle meningeal artery (MMA) and middle cerebral artery (MCA) using high resolution magnetic resonance angiography (MRA).Methods: In a double-blind, randomized, placebo-controlled study 14 healthy volunteers were scanned repeatedly after infusion (20 min) of 10 pmol/kg/min PACAP38 or placebo. In addition, four participants were scanned following subcutaneous sumatriptan (6 mg).Results: We found significant dilatation of the MMA (p = 0.00001), but not of the MCA (p = 0.50) after PACAP38. There was no change after placebo (p > 0.40). Vasodilatation (range 16-23%) lasted more than 5 h. Sumatriptan selectively contracted the MMA by 12.3% (p = 0.043).Conclusion: PACAP38-induced headache is associated with prolonged dilatation of the MMA but not of the MCA. Sumatriptan relieves headache in parallel with contraction of the MMA but not of the MCA.
U2 - 10.1177/0333102411431333
DO - 10.1177/0333102411431333
M3 - Journal article
C2 - 22174350
SN - 0800-1952
VL - 32
SP - 140
EP - 149
JO - Cephalalgia, Supplement
JF - Cephalalgia, Supplement
IS - 2
ER -