Gut microbiome development along the colorectal adenoma-carcinoma sequence

Qiang Feng; Suisha Liang; Huijue Jia; Andreas Stadlmayr; Longqing Tang; Zhou Lan; Dongya Zhang; Huihua Xia; Xiaoying Xu; Zhuye Jie; Lili Su; Xiaoping Li; Xin Li; Junhua Li; Liang Xiao; Ursula Huber-Schönauer; David Niederseer; Xun Xu; Jumana Yousuf Al-Aama; Huanming Yang; Jian Wang; Karsten Kristiansen; Manimozhiyan Arumugam; Herbert Tilg; Christian Datz; Jun Wang

doi:10.1038/ncomms7528

Gut microbiome development along the colorectal adenoma-carcinoma sequence

Qiang Feng, Suisha Liang, Huijue Jia, Andreas Stadlmayr, Longqing Tang, Zhou Lan, Dongya Zhang, Huihua Xia, Xiaoying Xu, Zhuye Jie, Lili Su, Xiaoping Li, Xin Li, Junhua Li, Liang Xiao, Ursula Huber-Schönauer, David Niederseer, Xun Xu, Jumana Yousuf Al-Aama, Huanming YangJian Wang, Karsten Kristiansen, Manimozhiyan Arumugam, Herbert Tilg, Christian Datz, Jun Wang

424 Citations (Scopus)

Abstract

Colorectal cancer, a commonly diagnosed cancer in the elderly, often develops slowly from benign polyps called adenoma. The gut microbiota is believed to be directly involved in colorectal carcinogenesis. The identity and functional capacity of the adenoma- or carcinoma-related gut microbe(s), however, have not been surveyed in a comprehensive manner. Here we perform a metagenome-wide association study (MGWAS) on stools from advanced adenoma and carcinoma patients and from healthy subjects, revealing microbial genes, strains and functions enriched in each group. An analysis of potential risk factors indicates that high intake of red meat relative to fruits and vegetables appears to associate with outgrowth of bacteria that might contribute to a more hostile gut environment. These findings suggest that faecal microbiome-based strategies may be useful for early diagnosis and treatment of colorectal adenoma or carcinoma.

Original language	English
Article number	6528
Journal	Nature Communications
Volume	6
Number of pages	13
ISSN	2041-1723
DOIs	https://doi.org/10.1038/ncomms7528
Publication status	Published - 11 Mar 2015

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Feng, Q., Liang, S., Jia, H., Stadlmayr, A., Tang, L., Lan, Z., Zhang, D., Xia, H., Xu, X., Jie, Z., Su, L., Li, X., Li, X., Li, J., Xiao, L., Huber-Schönauer, U., Niederseer, D., Xu, X., Al-Aama, J. Y., ... Wang, J. (2015). Gut microbiome development along the colorectal adenoma-carcinoma sequence. Nature Communications, 6, [6528]. https://doi.org/10.1038/ncomms7528

Feng, Q, Liang, S, Jia, H, Stadlmayr, A, Tang, L, Lan, Z, Zhang, D, Xia, H, Xu, X, Jie, Z, Su, L, Li, X, Li, X, Li, J, Xiao, L, Huber-Schönauer, U, Niederseer, D, Xu, X, Al-Aama, JY, Yang, H, Wang, J, Kristiansen, K , Arumugam, M, Tilg, H, Datz, C & Wang, J 2015, 'Gut microbiome development along the colorectal adenoma-carcinoma sequence', Nature Communications, vol. 6, 6528. https://doi.org/10.1038/ncomms7528

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title = "Gut microbiome development along the colorectal adenoma-carcinoma sequence",

abstract = "Colorectal cancer, a commonly diagnosed cancer in the elderly, often develops slowly from benign polyps called adenoma. The gut microbiota is believed to be directly involved in colorectal carcinogenesis. The identity and functional capacity of the adenoma- or carcinoma-related gut microbe(s), however, have not been surveyed in a comprehensive manner. Here we perform a metagenome-wide association study (MGWAS) on stools from advanced adenoma and carcinoma patients and from healthy subjects, revealing microbial genes, strains and functions enriched in each group. An analysis of potential risk factors indicates that high intake of red meat relative to fruits and vegetables appears to associate with outgrowth of bacteria that might contribute to a more hostile gut environment. These findings suggest that faecal microbiome-based strategies may be useful for early diagnosis and treatment of colorectal adenoma or carcinoma.",

author = "Qiang Feng and Suisha Liang and Huijue Jia and Andreas Stadlmayr and Longqing Tang and Zhou Lan and Dongya Zhang and Huihua Xia and Xiaoying Xu and Zhuye Jie and Lili Su and Xiaoping Li and Xin Li and Junhua Li and Liang Xiao and Ursula Huber-Sch{\"o}nauer and David Niederseer and Xun Xu and Al-Aama, {Jumana Yousuf} and Huanming Yang and Jian Wang and Karsten Kristiansen and Manimozhiyan Arumugam and Herbert Tilg and Christian Datz and Jun Wang",

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doi = "10.1038/ncomms7528",

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T1 - Gut microbiome development along the colorectal adenoma-carcinoma sequence

AU - Feng, Qiang

AU - Liang, Suisha

AU - Jia, Huijue

AU - Stadlmayr, Andreas

AU - Tang, Longqing

AU - Lan, Zhou

AU - Zhang, Dongya

AU - Xia, Huihua

AU - Xu, Xiaoying

AU - Jie, Zhuye

AU - Su, Lili

AU - Li, Xiaoping

AU - Li, Xin

AU - Li, Junhua

AU - Xiao, Liang

AU - Huber-Schönauer, Ursula

AU - Niederseer, David

AU - Xu, Xun

AU - Al-Aama, Jumana Yousuf

AU - Yang, Huanming

AU - Wang, Jian

AU - Kristiansen, Karsten

AU - Arumugam, Manimozhiyan

AU - Tilg, Herbert

AU - Datz, Christian

AU - Wang, Jun

PY - 2015/3/11

Y1 - 2015/3/11

N2 - Colorectal cancer, a commonly diagnosed cancer in the elderly, often develops slowly from benign polyps called adenoma. The gut microbiota is believed to be directly involved in colorectal carcinogenesis. The identity and functional capacity of the adenoma- or carcinoma-related gut microbe(s), however, have not been surveyed in a comprehensive manner. Here we perform a metagenome-wide association study (MGWAS) on stools from advanced adenoma and carcinoma patients and from healthy subjects, revealing microbial genes, strains and functions enriched in each group. An analysis of potential risk factors indicates that high intake of red meat relative to fruits and vegetables appears to associate with outgrowth of bacteria that might contribute to a more hostile gut environment. These findings suggest that faecal microbiome-based strategies may be useful for early diagnosis and treatment of colorectal adenoma or carcinoma.

AB - Colorectal cancer, a commonly diagnosed cancer in the elderly, often develops slowly from benign polyps called adenoma. The gut microbiota is believed to be directly involved in colorectal carcinogenesis. The identity and functional capacity of the adenoma- or carcinoma-related gut microbe(s), however, have not been surveyed in a comprehensive manner. Here we perform a metagenome-wide association study (MGWAS) on stools from advanced adenoma and carcinoma patients and from healthy subjects, revealing microbial genes, strains and functions enriched in each group. An analysis of potential risk factors indicates that high intake of red meat relative to fruits and vegetables appears to associate with outgrowth of bacteria that might contribute to a more hostile gut environment. These findings suggest that faecal microbiome-based strategies may be useful for early diagnosis and treatment of colorectal adenoma or carcinoma.

U2 - 10.1038/ncomms7528

DO - 10.1038/ncomms7528

M3 - Journal article

C2 - 25758642

SN - 2041-1723

VL - 6

JO - Nature Communications

JF - Nature Communications

M1 - 6528

ER -

Gut microbiome development along the colorectal adenoma-carcinoma sequence

Abstract

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