Gut: a key player in the pathogenesis of type 2 diabetes?

Giovanna Muscogiuri; Giancarlo Balercia; Luigi Barrea; Angelo Cignarelli; Francesco Giorgino; Jens J Holst; Daniela Laudisio; Francesco Orio; Giacomo Tirabassi; Annamaria Colao

doi:10.1080/10408398.2016.1252712

Gut: a key player in the pathogenesis of type 2 diabetes?

Giovanna Muscogiuri, Giancarlo Balercia, Luigi Barrea, Angelo Cignarelli, Francesco Giorgino, Jens J Holst, Daniela Laudisio, Francesco Orio, Giacomo Tirabassi, Annamaria Colao

Endocrinology and Metabolism

14 Citations (Scopus)

Abstract

The gut regulates glucose and energy homeostasis; thus, the presence of ingested nutrients into the gut activates sensing mechanisms that affect both glucose homeostasis and regulate food intake. Increasing evidence suggest that gut may also play a key role in the pathogenesis of type 2 diabetes which may be related to both the intestinal microbiological profile and patterns of gut hormones secretion. Intestinal microbiota includes trillions of microorganisms but its composition and function may be adversely affected in type 2 diabetes. The intestinal microbiota may be responsible of the secretion of molecules that may impair insulin secretion/action. At the same time, intestinal milieu regulates the secretion of hormones such as GLP-1, GIP, ghrelin, gastrin, somatostatin, CCK, serotonin, peptide YY, GLP-2, all of which importantly influence metabolism in general and in particular glucose metabolism. Thus, the aim of this paper is to review the current evidence on the role of the gut in the pathogenesis of type 2 diabetes, taking into account both hormonal and microbiological aspects.

Original language	English
Journal	Critical Reviews in Food Science and Nutrition
Volume	58
Issue number	8
Pages (from-to)	1294–1309
ISSN	1040-8398
DOIs	https://doi.org/10.1080/10408398.2016.1252712
Publication status	Published - 24 May 2018

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1080/10408398.2016.1252712

Cite this

@article{80f7b0d0f1924b9cac279c59b7078ba1,

title = "Gut: a key player in the pathogenesis of type 2 diabetes?",

abstract = "The gut regulates glucose and energy homeostasis; thus, the presence of ingested nutrients into the gut activates sensing mechanisms that affect both glucose homeostasis and regulate food intake. Increasing evidence suggest that gut may also play a key role in the pathogenesis of type 2 diabetes which may be related to both the intestinal microbiological profile and patterns of gut hormones secretion. Intestinal microbiota includes trillions of microorganisms but its composition and function may be adversely affected in type 2 diabetes. The intestinal microbiota may be responsible of the secretion of molecules that may impair insulin secretion/action. At the same time, intestinal milieu regulates the secretion of hormones such as GLP-1, GIP, ghrelin, gastrin, somatostatin, CCK, serotonin, peptide YY, GLP-2, all of which importantly influence metabolism in general and in particular glucose metabolism. Thus, the aim of this paper is to review the current evidence on the role of the gut in the pathogenesis of type 2 diabetes, taking into account both hormonal and microbiological aspects.",

author = "Giovanna Muscogiuri and Giancarlo Balercia and Luigi Barrea and Angelo Cignarelli and Francesco Giorgino and Holst, {Jens J} and Daniela Laudisio and Francesco Orio and Giacomo Tirabassi and Annamaria Colao",

year = "2018",

month = may,

day = "24",

doi = "10.1080/10408398.2016.1252712",

language = "English",

volume = "58",

pages = "1294–1309",

journal = "Critical Reviews in Food Science and Nutrition",

issn = "1040-8398",

publisher = "Taylor & Francis",

number = "8",

}

TY - JOUR

T1 - Gut

T2 - a key player in the pathogenesis of type 2 diabetes?

AU - Muscogiuri, Giovanna

AU - Balercia, Giancarlo

AU - Barrea, Luigi

AU - Cignarelli, Angelo

AU - Giorgino, Francesco

AU - Holst, Jens J

AU - Laudisio, Daniela

AU - Orio, Francesco

AU - Tirabassi, Giacomo

AU - Colao, Annamaria

PY - 2018/5/24

Y1 - 2018/5/24

N2 - The gut regulates glucose and energy homeostasis; thus, the presence of ingested nutrients into the gut activates sensing mechanisms that affect both glucose homeostasis and regulate food intake. Increasing evidence suggest that gut may also play a key role in the pathogenesis of type 2 diabetes which may be related to both the intestinal microbiological profile and patterns of gut hormones secretion. Intestinal microbiota includes trillions of microorganisms but its composition and function may be adversely affected in type 2 diabetes. The intestinal microbiota may be responsible of the secretion of molecules that may impair insulin secretion/action. At the same time, intestinal milieu regulates the secretion of hormones such as GLP-1, GIP, ghrelin, gastrin, somatostatin, CCK, serotonin, peptide YY, GLP-2, all of which importantly influence metabolism in general and in particular glucose metabolism. Thus, the aim of this paper is to review the current evidence on the role of the gut in the pathogenesis of type 2 diabetes, taking into account both hormonal and microbiological aspects.

AB - The gut regulates glucose and energy homeostasis; thus, the presence of ingested nutrients into the gut activates sensing mechanisms that affect both glucose homeostasis and regulate food intake. Increasing evidence suggest that gut may also play a key role in the pathogenesis of type 2 diabetes which may be related to both the intestinal microbiological profile and patterns of gut hormones secretion. Intestinal microbiota includes trillions of microorganisms but its composition and function may be adversely affected in type 2 diabetes. The intestinal microbiota may be responsible of the secretion of molecules that may impair insulin secretion/action. At the same time, intestinal milieu regulates the secretion of hormones such as GLP-1, GIP, ghrelin, gastrin, somatostatin, CCK, serotonin, peptide YY, GLP-2, all of which importantly influence metabolism in general and in particular glucose metabolism. Thus, the aim of this paper is to review the current evidence on the role of the gut in the pathogenesis of type 2 diabetes, taking into account both hormonal and microbiological aspects.

U2 - 10.1080/10408398.2016.1252712

DO - 10.1080/10408398.2016.1252712

M3 - Review

C2 - 27892685

SN - 1040-8398

VL - 58

SP - 1294

EP - 1309

JO - Critical Reviews in Food Science and Nutrition

JF - Critical Reviews in Food Science and Nutrition

IS - 8

ER -

Gut: a key player in the pathogenesis of type 2 diabetes?

Abstract

UN SDGs

Access to Document

Fingerprint

Cite this