Abstract
Members of the p120-catenin family associate with cadherins and regulate their stability at the plasma membrane. How p120-catenin limits cadherin endocytosis has long remained a mystery. In this issue, Nanes et al. (2012. J. Cell Biol. doi:10.1083/jcb.201205029) identify a conserved acidic motif within cadherins that acts as a physical platform for p120-catenin binding. However, in the absence of p120-catenin, the motif acts as an endocytic signal. These results provide new insight into p120-catenin's role as guardian of intercellular junction dynamics.
| Original language | English |
|---|---|
| Journal | Journal of Cell Biology |
| Volume | 199 |
| Issue number | 2 |
| Pages (from-to) | 211-214 |
| Number of pages | 4 |
| ISSN | 0021-9525 |
| DOIs |
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| Publication status | Published - 15 Oct 2012 |
| Externally published | Yes |
Keywords
- Adherens Junctions
- Animals
- Antigens, CD
- Cadherins
- Catenins
- Endocytosis
- Humans
- Comment
- Journal Article
- Research Support, N.I.H., Extramural
- Research Support, Non-U.S. Gov't