Guilt by association: what p120-catenin has to hide

TY - JOUR

T1 - Guilt by association

T2 - what p120-catenin has to hide

AU - Perez-Moreno, Mirna

AU - Fuchs, Elaine

PY - 2012/10/15

Y1 - 2012/10/15

N2 - Members of the p120-catenin family associate with cadherins and regulate their stability at the plasma membrane. How p120-catenin limits cadherin endocytosis has long remained a mystery. In this issue, Nanes et al. (2012. J. Cell Biol. doi:10.1083/jcb.201205029) identify a conserved acidic motif within cadherins that acts as a physical platform for p120-catenin binding. However, in the absence of p120-catenin, the motif acts as an endocytic signal. These results provide new insight into p120-catenin's role as guardian of intercellular junction dynamics.

AB - Members of the p120-catenin family associate with cadherins and regulate their stability at the plasma membrane. How p120-catenin limits cadherin endocytosis has long remained a mystery. In this issue, Nanes et al. (2012. J. Cell Biol. doi:10.1083/jcb.201205029) identify a conserved acidic motif within cadherins that acts as a physical platform for p120-catenin binding. However, in the absence of p120-catenin, the motif acts as an endocytic signal. These results provide new insight into p120-catenin's role as guardian of intercellular junction dynamics.

KW - Adherens Junctions

KW - Animals

KW - Antigens, CD

KW - Cadherins

KW - Catenins

KW - Endocytosis

KW - Humans

KW - Comment

KW - Journal Article

KW - Research Support, N.I.H., Extramural

KW - Research Support, Non-U.S. Gov't

U2 - 10.1083/jcb.201209014

DO - 10.1083/jcb.201209014

M3 - Comment/debate

C2 - 23071151

SN - 0021-9525

VL - 199

SP - 211

EP - 214

JO - Journal of Cell Biology

JF - Journal of Cell Biology

IS - 2

ER -