Guaianolide Sesquiterpenoids: Pharmacology and biosynthesis

Henrik Toft Simonsen; Corinna Weitzel; Søren Brøgger Christensen

doi:10.1007/978-3-642-22144-6_134

Guaianolide Sesquiterpenoids: Pharmacology and biosynthesis

Henrik Toft Simonsen, Corinna Weitzel, Søren Brøgger Christensen

Section for Plant Biochemistry

42 Citations (Scopus)

Abstract

Guaianolides are a large group of sesquiterpene lactones of chemotaxonomic as well as biological importance. The ability of the thapsigargins isolated from the genus Thapsia(Apiaceae) to inhibit an intracellular calcium pump and thereby inducing apoptosis has encouraged intensive research in order to develop a new drug, which at present is in clinical trial toward cancer diseases. Several other guaianolides have been investigated as chemotaxonomic markers. In particular, α-methylene guaianolides and guaianolides containing an α,β-unsaturated carbonyl moiety show biological activities.

Original language	English
Title of host publication	Natural products : phytochemistry, botany and metabolism of alkaloids, phenolics and terpenes
Editors	Kishan Gopal Ramawat, Jean-Michel Mérillon
Number of pages	30
Publisher	Springer
Publication date	1 Jan 2013
Pages	3069-3098
Chapter	98
ISBN (Print)	978-3-642-22143-9
ISBN (Electronic)	978-3-642-22144-6
DOIs	https://doi.org/10.1007/978-3-642-22144-6_134
Publication status	Published - 1 Jan 2013

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Guaianolide Sesquiterpenoids: Pharmacology and biosynthesis. / Simonsen, Henrik Toft; Weitzel, Corinna; Christensen, Søren Brøgger.
Natural products: phytochemistry, botany and metabolism of alkaloids, phenolics and terpenes. ed. / Kishan Gopal Ramawat; Jean-Michel Mérillon. Springer, 2013. p. 3069-3098.

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

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Guaianolide Sesquiterpenoids: Pharmacology and biosynthesis

Abstract

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