Guaianolide Sesquiterpenoids: Pharmacology and biosynthesis

TY - CHAP

T1 - Guaianolide Sesquiterpenoids

T2 - Pharmacology and biosynthesis

AU - Simonsen, Henrik Toft

AU - Weitzel, Corinna

AU - Christensen, Søren Brøgger

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Guaianolides are a large group of sesquiterpene lactones of chemotaxonomic as well as biological importance. The ability of the thapsigargins isolated from the genus Thapsia(Apiaceae) to inhibit an intracellular calcium pump and thereby inducing apoptosis has encouraged intensive research in order to develop a new drug, which at present is in clinical trial toward cancer diseases. Several other guaianolides have been investigated as chemotaxonomic markers. In particular, α-methylene guaianolides and guaianolides containing an α,β-unsaturated carbonyl moiety show biological activities.

AB - Guaianolides are a large group of sesquiterpene lactones of chemotaxonomic as well as biological importance. The ability of the thapsigargins isolated from the genus Thapsia(Apiaceae) to inhibit an intracellular calcium pump and thereby inducing apoptosis has encouraged intensive research in order to develop a new drug, which at present is in clinical trial toward cancer diseases. Several other guaianolides have been investigated as chemotaxonomic markers. In particular, α-methylene guaianolides and guaianolides containing an α,β-unsaturated carbonyl moiety show biological activities.

U2 - 10.1007/978-3-642-22144-6_134

DO - 10.1007/978-3-642-22144-6_134

M3 - Book chapter

SN - 978-3-642-22143-9

SP - 3069

EP - 3098

BT - Natural products

A2 - Ramawat, Kishan Gopal

A2 - Mérillon, Jean-Michel

PB - Springer

ER -