GPCR-Mediated Signaling of Metabolites

TY - JOUR

T1 - GPCR-Mediated Signaling of Metabolites

AU - Husted, Anna Sofie

AU - Trauelsen, Mette

AU - Rudenko, Olga

AU - Hjorth, Siv A

AU - Schwartz, Thue W

N1 - Copyright © 2017 Elsevier Inc. All rights reserved.

PY - 2017/4/4

Y1 - 2017/4/4

N2 - In addition to their bioenergetic intracellular function, several classical metabolites act as extracellular signaling molecules activating cell-surface G-protein-coupled receptors (GPCRs), similar to hormones and neurotransmitters. "Signaling metabolites" generated from nutrients or by gut microbiota target primarily enteroendocrine, neuronal, and immune cells in the lamina propria of the gut mucosa and the liver and, through these tissues, the rest of the body. In contrast, metabolites from the intermediary metabolism act mainly as metabolic stress-induced autocrine and paracrine signals in adipose tissue, the liver, and the endocrine pancreas. Importantly, distinct metabolite GPCRs act as efficient pro- and anti-inflammatory regulators of key immune cells, and signaling metabolites may thus function as important drivers of the low-grade inflammation associated with insulin resistance and obesity. The concept of key metabolites as ligands for specific GPCRs has broadened our understanding of metabolic signaling significantly and provides a number of novel potential drug targets.

AB - In addition to their bioenergetic intracellular function, several classical metabolites act as extracellular signaling molecules activating cell-surface G-protein-coupled receptors (GPCRs), similar to hormones and neurotransmitters. "Signaling metabolites" generated from nutrients or by gut microbiota target primarily enteroendocrine, neuronal, and immune cells in the lamina propria of the gut mucosa and the liver and, through these tissues, the rest of the body. In contrast, metabolites from the intermediary metabolism act mainly as metabolic stress-induced autocrine and paracrine signals in adipose tissue, the liver, and the endocrine pancreas. Importantly, distinct metabolite GPCRs act as efficient pro- and anti-inflammatory regulators of key immune cells, and signaling metabolites may thus function as important drivers of the low-grade inflammation associated with insulin resistance and obesity. The concept of key metabolites as ligands for specific GPCRs has broadened our understanding of metabolic signaling significantly and provides a number of novel potential drug targets.

KW - Journal Article

KW - Review

U2 - 10.1016/j.cmet.2017.03.008

DO - 10.1016/j.cmet.2017.03.008

M3 - Review

C2 - 28380372

SN - 1550-4131

VL - 25

SP - 777

EP - 796

JO - Cell Metabolism

JF - Cell Metabolism

IS - 4

ER -