Abstract
The brain is one of the most metabolically active organs in the body, and continuous removal of excess fluid and waste products is critical for normal brain function. In contrast to other body organs, the brain lack lymphatic vessels for detoxification. In place of lymphatic vessels, the brain uses a so-called glymphatic pathway which comprise the peri-vascular space and acuaporin-4 water channels on astroglial endfeet. As such the glymphatic pathway can be perceived as a hitherto overlooked compartment of the extracellular space of the central nervous system which is involved in clearance of amyloid-beta and other neurotoxic waste substances that build up in the brain.
| Original language | English |
|---|---|
| Title of host publication | Neuroscience in the 21st Century : From Basic to Clinical |
| Number of pages | 18 |
| Publisher | Springer |
| Publication date | 2016 |
| Edition | 2 |
| Pages | 1945-1962 |
| Chapter | 63 |
| ISBN (Print) | 978-1-4939-3473-7 |
| ISBN (Electronic) | 978-1-4939-3474-4 |
| DOIs | |
| Publication status | Published - 2016 |
Keywords
- AQP4 water channels
- AQP4 water channels, polarity and density of
- Aquaporin-4 (AQP4) water channels
- Blood-brain barrier (BBB)
- Body posture
- Cerebrospinal fluid (CSF)
- Chronic traumatic encephalopathy (CTE)
- CSF-ISF, efflux pathways
- Glymphatic system
- Horseradish peroxidase (HRP)
- Interstitial fluid (ISF)
- Interstitial space size
- Protein waste products, removal of
- TBI
- Traumatic brain injury (TBI)
- Vascular pulsatility