TY - CHAP
T1 - Glymphatic system
AU - Benveniste, Helene
AU - Nedergaard, Maiken
PY - 2016
Y1 - 2016
N2 - The brain is one of the most metabolically active organs in the body, and continuous removal of excess fluid and waste products is critical for normal brain function. In contrast to other body organs, the brain lack lymphatic vessels for detoxification. In place of lymphatic vessels, the brain uses a so-called glymphatic pathway which comprise the peri-vascular space and acuaporin-4 water channels on astroglial endfeet. As such the glymphatic pathway can be perceived as a hitherto overlooked compartment of the extracellular space of the central nervous system which is involved in clearance of amyloid-beta and other neurotoxic waste substances that build up in the brain.
AB - The brain is one of the most metabolically active organs in the body, and continuous removal of excess fluid and waste products is critical for normal brain function. In contrast to other body organs, the brain lack lymphatic vessels for detoxification. In place of lymphatic vessels, the brain uses a so-called glymphatic pathway which comprise the peri-vascular space and acuaporin-4 water channels on astroglial endfeet. As such the glymphatic pathway can be perceived as a hitherto overlooked compartment of the extracellular space of the central nervous system which is involved in clearance of amyloid-beta and other neurotoxic waste substances that build up in the brain.
KW - AQP4 water channels
KW - AQP4 water channels, polarity and density of
KW - Aquaporin-4 (AQP4) water channels
KW - Blood-brain barrier (BBB)
KW - Body posture
KW - Cerebrospinal fluid (CSF)
KW - Chronic traumatic encephalopathy (CTE)
KW - CSF-ISF, efflux pathways
KW - Glymphatic system
KW - Horseradish peroxidase (HRP)
KW - Interstitial fluid (ISF)
KW - Interstitial space size
KW - Protein waste products, removal of
KW - TBI
KW - Traumatic brain injury (TBI)
KW - Vascular pulsatility
U2 - 10.1007/978-1-4939-3474-4_138
DO - 10.1007/978-1-4939-3474-4_138
M3 - Book chapter
AN - SCOPUS:85018935128
SN - 978-1-4939-3473-7
SP - 1945
EP - 1962
BT - Neuroscience in the 21st Century
PB - Springer
ER -