Glycosylation Engineering

Henrik Clausen; Hans H. Wandall; Catharina Steentoft; Pamela Stanley; Ronald L Schnaar

Glycosylation Engineering

Henrik Clausen, Hans H. Wandall, Catharina Steentoft, Pamela Stanley, Ronald L Schnaar

Glycomics Program

Abstract

Knowledge of the cellular pathways of glycosylation across phylogeny provides opportunities for designing glycans via genetic engineering in a wide variety of cell types including bacteria, fungi, plant cells, and mammalian cells. The commercial demand for glycosylation engineering is broad, including production of biological therapeutics with defined glycosylation (Chapter 57). This chapter describes how knowledge of glycan structures and their metabolism (Parts I–III of this book) has led to the current state of glycosylation engineering in different cell types. Perspectives for rapid advances in this area using precise gene editing technologies are also described.

Original language	English
Title of host publication	Essentials of Glycobiology
Publisher	Cold Spring Harbor Laboratory Press
Publication date	2017
Edition	3
Chapter	56
ISBN (Print)	978-1-621821-32-8
Publication status	Published - 2017

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title = "Glycosylation Engineering",

abstract = "Knowledge of the cellular pathways of glycosylation across phylogeny provides opportunities for designing glycans via genetic engineering in a wide variety of cell types including bacteria, fungi, plant cells, and mammalian cells. The commercial demand for glycosylation engineering is broad, including production of biological therapeutics with defined glycosylation (Chapter 57). This chapter describes how knowledge of glycan structures and their metabolism (Parts I–III of this book) has led to the current state of glycosylation engineering in different cell types. Perspectives for rapid advances in this area using precise gene editing technologies are also described.",

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AU - Clausen, Henrik

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AU - Steentoft, Catharina

AU - Stanley, Pamela

AU - Schnaar, Ronald L

PY - 2017

Y1 - 2017

N2 - Knowledge of the cellular pathways of glycosylation across phylogeny provides opportunities for designing glycans via genetic engineering in a wide variety of cell types including bacteria, fungi, plant cells, and mammalian cells. The commercial demand for glycosylation engineering is broad, including production of biological therapeutics with defined glycosylation (Chapter 57). This chapter describes how knowledge of glycan structures and their metabolism (Parts I–III of this book) has led to the current state of glycosylation engineering in different cell types. Perspectives for rapid advances in this area using precise gene editing technologies are also described.

AB - Knowledge of the cellular pathways of glycosylation across phylogeny provides opportunities for designing glycans via genetic engineering in a wide variety of cell types including bacteria, fungi, plant cells, and mammalian cells. The commercial demand for glycosylation engineering is broad, including production of biological therapeutics with defined glycosylation (Chapter 57). This chapter describes how knowledge of glycan structures and their metabolism (Parts I–III of this book) has led to the current state of glycosylation engineering in different cell types. Perspectives for rapid advances in this area using precise gene editing technologies are also described.

M3 - Book chapter

SN - 978-1-621821-32-8

BT - Essentials of Glycobiology

PB - Cold Spring Harbor Laboratory Press

ER -

Glycosylation Engineering

Abstract

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