Glycosylation Engineering

Henrik Clausen; Hans H. Wandall; Catharina Steentoft; Pamela Stanley; Ronald L Schnaar

Glycosylation Engineering

Henrik Clausen, Hans H. Wandall, Catharina Steentoft, Pamela Stanley, Ronald L Schnaar

Glycomics Program

Abstract

Knowledge of the cellular pathways of glycosylation across phylogeny provides opportunities for designing glycans via genetic engineering in a wide variety of cell types including bacteria, fungi, plant cells, and mammalian cells. The commercial demand for glycosylation engineering is broad, including production of biological therapeutics with defined glycosylation (Chapter 57). This chapter describes how knowledge of glycan structures and their metabolism (Parts I–III of this book) has led to the current state of glycosylation engineering in different cell types. Perspectives for rapid advances in this area using precise gene editing technologies are also described.

Originalsprog	Engelsk
Titel	Essentials of Glycobiology
Forlag	Cold Spring Harbor Laboratory Press
Publikationsdato	2017
Udgave	3
Kapitel	56
ISBN (Trykt)	978-1-621821-32-8
Status	Udgivet - 2017

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https://www.ncbi.nlm.nih.gov/books/NBK453027/Licens: Ikke-specificeret

Citationsformater

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AU - Stanley, Pamela

AU - Schnaar, Ronald L

PY - 2017

Y1 - 2017

N2 - Knowledge of the cellular pathways of glycosylation across phylogeny provides opportunities for designing glycans via genetic engineering in a wide variety of cell types including bacteria, fungi, plant cells, and mammalian cells. The commercial demand for glycosylation engineering is broad, including production of biological therapeutics with defined glycosylation (Chapter 57). This chapter describes how knowledge of glycan structures and their metabolism (Parts I–III of this book) has led to the current state of glycosylation engineering in different cell types. Perspectives for rapid advances in this area using precise gene editing technologies are also described.

AB - Knowledge of the cellular pathways of glycosylation across phylogeny provides opportunities for designing glycans via genetic engineering in a wide variety of cell types including bacteria, fungi, plant cells, and mammalian cells. The commercial demand for glycosylation engineering is broad, including production of biological therapeutics with defined glycosylation (Chapter 57). This chapter describes how knowledge of glycan structures and their metabolism (Parts I–III of this book) has led to the current state of glycosylation engineering in different cell types. Perspectives for rapid advances in this area using precise gene editing technologies are also described.

M3 - Book chapter

SN - 978-1-621821-32-8

BT - Essentials of Glycobiology

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Glycosylation Engineering

Abstract

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