Glucose-neopentyl glycol (GNG) amphiphiles for membrane protein study

Pil Seok Chae; Rohini R Rana; Kamil Gotfryd; Søren G F Rasmussen; Andrew C Kruse; Kyung Ho Cho; Stefano Capaldi; Emil Carlsson; Brian Kobilka; Claus J Loland; Ulrik Gether; Surajit Banerjee; Bernadette Byrne; John K Lee; Samuel H Gellman

doi:10.1039/c2cc36844g

Glucose-neopentyl glycol (GNG) amphiphiles for membrane protein study

Pil Seok Chae, Rohini R Rana, Kamil Gotfryd, Søren G F Rasmussen, Andrew C Kruse, Kyung Ho Cho, Stefano Capaldi, Emil Carlsson, Brian Kobilka, Claus J Loland, Ulrik Gether, Surajit Banerjee, Bernadette Byrne, John K Lee, Samuel H Gellman

Neuropharm and Genetics

61 Citations (Scopus)

Abstract

The development of a new class of surfactants for membrane protein manipulation, "GNG amphiphiles", is reported. These amphiphiles display promising behavior for membrane proteins, as demonstrated recently by the high resolution structure of a sodium-pumping pyrophosphatase reported by Kellosalo et al. (Science, 2012, 337, 473).

Original language	English
Journal	Chemical communications (Cambridge, England)
Volume	49
Issue number	23
Pages (from-to)	2287-9
Number of pages	3
ISSN	1359-7345
DOIs	https://doi.org/10.1039/c2cc36844g
Publication status	Published - 21 Feb 2013

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Chae, P. S., Rana, R. R., Gotfryd, K., Rasmussen, S. G. F., Kruse, A. C., Cho, K. H., Capaldi, S., Carlsson, E., Kobilka, B., Loland, C. J., Gether, U., Banerjee, S., Byrne, B., Lee, J. K., & Gellman, S. H. (2013). Glucose-neopentyl glycol (GNG) amphiphiles for membrane protein study. Chemical communications (Cambridge, England), 49(23), 2287-9. https://doi.org/10.1039/c2cc36844g

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AU - Chae, Pil Seok

AU - Rana, Rohini R

AU - Gotfryd, Kamil

AU - Rasmussen, Søren G F

AU - Kruse, Andrew C

AU - Cho, Kyung Ho

AU - Capaldi, Stefano

AU - Carlsson, Emil

AU - Kobilka, Brian

AU - Loland, Claus J

AU - Gether, Ulrik

AU - Banerjee, Surajit

AU - Byrne, Bernadette

AU - Lee, John K

AU - Gellman, Samuel H

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AB - The development of a new class of surfactants for membrane protein manipulation, "GNG amphiphiles", is reported. These amphiphiles display promising behavior for membrane proteins, as demonstrated recently by the high resolution structure of a sodium-pumping pyrophosphatase reported by Kellosalo et al. (Science, 2012, 337, 473).

U2 - 10.1039/c2cc36844g

DO - 10.1039/c2cc36844g

M3 - Journal article

C2 - 23165475

SN - 1359-7345

VL - 49

SP - 2287

EP - 2289

JO - Chemical Communications

JF - Chemical Communications

IS - 23

ER -

Glucose-neopentyl glycol (GNG) amphiphiles for membrane protein study

Abstract

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