Glucagon regulation of energy expenditure

Maximilian Kleinert; Stephan Sachs; Kirk M Habegger; Susanna M Hofmann; Timo D Müller

doi:10.3390/ijms20215407

Glucagon regulation of energy expenditure

Maximilian Kleinert, Stephan Sachs, Kirk M Habegger, Susanna M Hofmann, Timo D Müller^*

^*Corresponding author for this work

The August Krogh Section for Molecular Physiology

9 Citations (Scopus)

3 Downloads (Pure)

Abstract

Glucagon’s ability to increase energy expenditure has been known for more than 60 years, yet the mechanisms underlining glucagon’s thermogenic effect still remain largely elusive. Over the last years, significant efforts were directed to unravel the physiological and cellular underpinnings of how glucagon regulates energy expenditure. In this review, we summarize the current knowledge on how glucagon regulates systems metabolism with a special emphasis on its acute and chronic thermogenic effects.

Original language	English
Article number	5407
Journal	International Journal of Molecular Sciences
Volume	20
Issue number	21
Number of pages	12
ISSN	1661-6596
DOIs	https://doi.org/10.3390/ijms20215407
Publication status	Published - 2019

Keywords

Brown adipose tissue
Energy expenditure
FGF21
Glucagon
Obesity
Pharmacology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/ijms20215407

Kleinert et al_International Journal of Molecular Sciences_2019_Vol 20(21)_e5407Final published version, 665 KBLicence: CC BY

Cite this

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AU - Kleinert, Maximilian

AU - Sachs, Stephan

AU - Habegger, Kirk M

AU - Hofmann, Susanna M

AU - Müller, Timo D

N1 - CURIS 2019 NEXS 368

PY - 2019

Y1 - 2019

N2 - Glucagon’s ability to increase energy expenditure has been known for more than 60 years, yet the mechanisms underlining glucagon’s thermogenic effect still remain largely elusive. Over the last years, significant efforts were directed to unravel the physiological and cellular underpinnings of how glucagon regulates energy expenditure. In this review, we summarize the current knowledge on how glucagon regulates systems metabolism with a special emphasis on its acute and chronic thermogenic effects.

AB - Glucagon’s ability to increase energy expenditure has been known for more than 60 years, yet the mechanisms underlining glucagon’s thermogenic effect still remain largely elusive. Over the last years, significant efforts were directed to unravel the physiological and cellular underpinnings of how glucagon regulates energy expenditure. In this review, we summarize the current knowledge on how glucagon regulates systems metabolism with a special emphasis on its acute and chronic thermogenic effects.

KW - Brown adipose tissue

KW - Energy expenditure

KW - FGF21

KW - Glucagon

KW - Obesity

KW - Pharmacology

U2 - 10.3390/ijms20215407

DO - 10.3390/ijms20215407

M3 - Review

C2 - 31671603

AN - SCOPUS:85074370668

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ER -

Glucagon regulation of energy expenditure

Abstract

Keywords

UN SDGs

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