Glucagon regulation of energy expenditure

Maximilian Kleinert; Stephan Sachs; Kirk M Habegger; Susanna M Hofmann; Timo D Müller

doi:10.3390/ijms20215407

Glucagon regulation of energy expenditure

Maximilian Kleinert, Stephan Sachs, Kirk M Habegger, Susanna M Hofmann, Timo D Müller^*

^*Corresponding author af dette arbejde

August Krogh Sektionen for Molekylær Fysiologi

9 Citationer (Scopus)

3 Downloads (Pure)

Abstract

Glucagon’s ability to increase energy expenditure has been known for more than 60 years, yet the mechanisms underlining glucagon’s thermogenic effect still remain largely elusive. Over the last years, significant efforts were directed to unravel the physiological and cellular underpinnings of how glucagon regulates energy expenditure. In this review, we summarize the current knowledge on how glucagon regulates systems metabolism with a special emphasis on its acute and chronic thermogenic effects.

Originalsprog	Engelsk
Artikelnummer	5407
Tidsskrift	International Journal of Molecular Sciences
Vol/bind	20
Udgave nummer	21
Antal sider	12
ISSN	1661-6596
DOI	https://doi.org/10.3390/ijms20215407
Status	Udgivet - 2019

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10.3390/ijms20215407

Kleinert et al_International Journal of Molecular Sciences_2019_Vol 20(21)_e5407Forlagets udgivne version, 665 KBLicens: CC BY

Citationsformater

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AU - Kleinert, Maximilian

AU - Sachs, Stephan

AU - Habegger, Kirk M

AU - Hofmann, Susanna M

AU - Müller, Timo D

N1 - CURIS 2019 NEXS 368

PY - 2019

Y1 - 2019

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AB - Glucagon’s ability to increase energy expenditure has been known for more than 60 years, yet the mechanisms underlining glucagon’s thermogenic effect still remain largely elusive. Over the last years, significant efforts were directed to unravel the physiological and cellular underpinnings of how glucagon regulates energy expenditure. In this review, we summarize the current knowledge on how glucagon regulates systems metabolism with a special emphasis on its acute and chronic thermogenic effects.

KW - Brown adipose tissue

KW - Energy expenditure

KW - FGF21

KW - Glucagon

KW - Obesity

KW - Pharmacology

U2 - 10.3390/ijms20215407

DO - 10.3390/ijms20215407

M3 - Review

C2 - 31671603

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SN - 1661-6596

VL - 20

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

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ER -

Glucagon regulation of energy expenditure

Abstract

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