Glucagon regulation of energy expenditure

Maximilian Kleinert; Stephan Sachs; Kirk M Habegger; Susanna M Hofmann; Timo D Müller

doi:10.3390/ijms20215407

Glucagon regulation of energy expenditure

Maximilian Kleinert, Stephan Sachs, Kirk M Habegger, Susanna M Hofmann, Timo D Müller^*

^*Corresponding author af dette arbejde

August Krogh Sektionen for Molekylær Fysiologi

9 Citationer (Scopus)

3 Downloads (Pure)

Abstract

Glucagon’s ability to increase energy expenditure has been known for more than 60 years, yet the mechanisms underlining glucagon’s thermogenic effect still remain largely elusive. Over the last years, significant efforts were directed to unravel the physiological and cellular underpinnings of how glucagon regulates energy expenditure. In this review, we summarize the current knowledge on how glucagon regulates systems metabolism with a special emphasis on its acute and chronic thermogenic effects.

Originalsprog	Engelsk
Artikelnummer	5407
Tidsskrift	International Journal of Molecular Sciences
Vol/bind	20
Udgave nummer	21
Antal sider	12
ISSN	1661-6596
DOI	https://doi.org/10.3390/ijms20215407
Status	Udgivet - 2019

FN’s Verdensmål

Dette resultat bidrager til følgende verdensmål

Adgang til dokumentet

10.3390/ijms20215407

Kleinert et al_International Journal of Molecular Sciences_2019_Vol 20(21)_e5407Forlagets udgivne version, 665 KBLicens: CC BY

Citationsformater

@article{b1ad5333a5af4eca9f5ba21d054bcea2,

title = "Glucagon regulation of energy expenditure",

abstract = "Glucagon{\textquoteright}s ability to increase energy expenditure has been known for more than 60 years, yet the mechanisms underlining glucagon{\textquoteright}s thermogenic effect still remain largely elusive. Over the last years, significant efforts were directed to unravel the physiological and cellular underpinnings of how glucagon regulates energy expenditure. In this review, we summarize the current knowledge on how glucagon regulates systems metabolism with a special emphasis on its acute and chronic thermogenic effects.",

keywords = "Brown adipose tissue, Energy expenditure, FGF21, Glucagon, Obesity, Pharmacology",

author = "Maximilian Kleinert and Stephan Sachs and Habegger, {Kirk M} and Hofmann, {Susanna M} and M{\"u}ller, {Timo D}",

note = "CURIS 2019 NEXS 368",

year = "2019",

doi = "10.3390/ijms20215407",

language = "English",

volume = "20",

journal = "International Journal of Molecular Sciences (CD-ROM)",

issn = "1424-6783",

publisher = "M D P I AG",

number = "21",

}

TY - JOUR

T1 - Glucagon regulation of energy expenditure

AU - Kleinert, Maximilian

AU - Sachs, Stephan

AU - Habegger, Kirk M

AU - Hofmann, Susanna M

AU - Müller, Timo D

N1 - CURIS 2019 NEXS 368

PY - 2019

Y1 - 2019

N2 - Glucagon’s ability to increase energy expenditure has been known for more than 60 years, yet the mechanisms underlining glucagon’s thermogenic effect still remain largely elusive. Over the last years, significant efforts were directed to unravel the physiological and cellular underpinnings of how glucagon regulates energy expenditure. In this review, we summarize the current knowledge on how glucagon regulates systems metabolism with a special emphasis on its acute and chronic thermogenic effects.

AB - Glucagon’s ability to increase energy expenditure has been known for more than 60 years, yet the mechanisms underlining glucagon’s thermogenic effect still remain largely elusive. Over the last years, significant efforts were directed to unravel the physiological and cellular underpinnings of how glucagon regulates energy expenditure. In this review, we summarize the current knowledge on how glucagon regulates systems metabolism with a special emphasis on its acute and chronic thermogenic effects.

KW - Brown adipose tissue

KW - Energy expenditure

KW - FGF21

KW - Glucagon

KW - Obesity

KW - Pharmacology

U2 - 10.3390/ijms20215407

DO - 10.3390/ijms20215407

M3 - Review

C2 - 31671603

AN - SCOPUS:85074370668

SN - 1424-6783

VL - 20

JO - International Journal of Molecular Sciences (CD-ROM)

JF - International Journal of Molecular Sciences (CD-ROM)

IS - 21

M1 - 5407

ER -

Glucagon regulation of energy expenditure

Abstract

FN’s Verdensmål

Adgang til dokumentet

Fingeraftryk

Citationsformater