Glucagon-like peptide 2 improves nutrient absorption and nutritional status in short-bowel patients with no colon

P B Jeppesen; B Hartmann; J Thulesen; J Graff; J Lohmann; B S Hansen; F Tofteng; Steen Seier Poulsen; J L Madsen; J J Holst; P B Mortensen

Glucagon-like peptide 2 improves nutrient absorption and nutritional status in short-bowel patients with no colon

P B Jeppesen, B Hartmann, J Thulesen, J Graff, J Lohmann, B S Hansen, F Tofteng, Steen Seier Poulsen, J L Madsen, J J Holst, P B Mortensen

411 Citations (Scopus)

Abstract

Glucagon-like peptide 2 (GLP-2) is intestinotrophic, antisecretory, and transit-modulating in rodents, and it is mainly secreted from the intestinal mucosa of the terminal ileum and colon after food ingestion. We assessed the effect of GLP-2 on the gastrointestinal function in patients without a terminal ileum and colon who have functional short-bowel syndrome with severe malabsorption of wet weight (>1.5 kg/day) and energy (>2.3 MJ/day) and no postprandial secretion of GLP-2.

Original language	English
Journal	Gastroenterology
Volume	120
Issue number	4
Pages (from-to)	806-815
Number of pages	10
ISSN	0016-5085
Publication status	Published - Mar 2001

Keywords

Adult
Body Composition
Body Weight
Creatinine
Female
Gastrointestinal Hormones
Gastrointestinal Transit
Glucagon-Like Peptide 2
Glucagon-Like Peptides
Hormones
Humans
Injections, Subcutaneous
Intestinal Absorption
Intestines
Male
Middle Aged
Nutritional Status
Patient Compliance
Peptides
Short Bowel Syndrome

Cite this

@article{693ed14074c711dbbee902004c4f4f50,

title = "Glucagon-like peptide 2 improves nutrient absorption and nutritional status in short-bowel patients with no colon",

abstract = "Glucagon-like peptide 2 (GLP-2) is intestinotrophic, antisecretory, and transit-modulating in rodents, and it is mainly secreted from the intestinal mucosa of the terminal ileum and colon after food ingestion. We assessed the effect of GLP-2 on the gastrointestinal function in patients without a terminal ileum and colon who have functional short-bowel syndrome with severe malabsorption of wet weight (>1.5 kg/day) and energy (>2.3 MJ/day) and no postprandial secretion of GLP-2.",

keywords = "Adult, Body Composition, Body Weight, Creatinine, Female, Gastrointestinal Hormones, Gastrointestinal Transit, Glucagon-Like Peptide 2, Glucagon-Like Peptides, Hormones, Humans, Injections, Subcutaneous, Intestinal Absorption, Intestines, Male, Middle Aged, Nutritional Status, Patient Compliance, Peptides, Short Bowel Syndrome",

author = "Jeppesen, {P B} and B Hartmann and J Thulesen and J Graff and J Lohmann and Hansen, {B S} and F Tofteng and Poulsen, {Steen Seier} and Madsen, {J L} and Holst, {J J} and Mortensen, {P B}",

year = "2001",

month = mar,

language = "English",

volume = "120",

pages = "806--815",

journal = "Gastroenterology",

issn = "0016-5085",

publisher = "Elsevier",

number = "4",

}

TY - JOUR

T1 - Glucagon-like peptide 2 improves nutrient absorption and nutritional status in short-bowel patients with no colon

AU - Jeppesen, P B

AU - Hartmann, B

AU - Thulesen, J

AU - Graff, J

AU - Lohmann, J

AU - Hansen, B S

AU - Tofteng, F

AU - Poulsen, Steen Seier

AU - Madsen, J L

AU - Holst, J J

AU - Mortensen, P B

PY - 2001/3

Y1 - 2001/3

N2 - Glucagon-like peptide 2 (GLP-2) is intestinotrophic, antisecretory, and transit-modulating in rodents, and it is mainly secreted from the intestinal mucosa of the terminal ileum and colon after food ingestion. We assessed the effect of GLP-2 on the gastrointestinal function in patients without a terminal ileum and colon who have functional short-bowel syndrome with severe malabsorption of wet weight (>1.5 kg/day) and energy (>2.3 MJ/day) and no postprandial secretion of GLP-2.

AB - Glucagon-like peptide 2 (GLP-2) is intestinotrophic, antisecretory, and transit-modulating in rodents, and it is mainly secreted from the intestinal mucosa of the terminal ileum and colon after food ingestion. We assessed the effect of GLP-2 on the gastrointestinal function in patients without a terminal ileum and colon who have functional short-bowel syndrome with severe malabsorption of wet weight (>1.5 kg/day) and energy (>2.3 MJ/day) and no postprandial secretion of GLP-2.

KW - Adult

KW - Body Composition

KW - Body Weight

KW - Creatinine

KW - Female

KW - Gastrointestinal Hormones

KW - Gastrointestinal Transit

KW - Glucagon-Like Peptide 2

KW - Glucagon-Like Peptides

KW - Hormones

KW - Humans

KW - Injections, Subcutaneous

KW - Intestinal Absorption

KW - Intestines

KW - Male

KW - Middle Aged

KW - Nutritional Status

KW - Patient Compliance

KW - Peptides

KW - Short Bowel Syndrome

M3 - Journal article

C2 - 11231933

SN - 0016-5085

VL - 120

SP - 806

EP - 815

JO - Gastroenterology

JF - Gastroenterology

IS - 4

ER -

Glucagon-like peptide 2 improves nutrient absorption and nutritional status in short-bowel patients with no colon

Abstract

Keywords

Fingerprint

Cite this