GLP-1 increases microvascular recruitment but not glucose uptake in human and rat skeletal muscle

Kim Anker Sjøberg; Jens Juul Holst; Stephen Rattigan; Erik Richter; Bente Kiens

doi:10.1152/ajpendo.00283.2013

GLP-1 increases microvascular recruitment but not glucose uptake in human and rat skeletal muscle

Kim Anker Sjøberg, Jens Juul Holst, Stephen Rattigan, Erik Richter, Bente Kiens

The August Krogh Section for Molecular Physiology

37 Citations (Scopus)

Abstract

The insulinotropic gut hormone, glucagon-like-peptide-1 (GLP-1) has been proposed to have effects on vascular function and glucose disposal. However, whether GLP-1 is able to increase microvascular recruitment (MVR) in humans has not been investigated. GLP-1 was infused in the femoral artery in overnight fasted healthy young men. Microvascular recruitment was measured with real time contrast-enhanced ultrasound and leg glucose uptake by the leg balance technique with and without inhibition of the insulinotropic response of GLP-1 by co-infusion of octreotide. As a positive control, MVR and leg glucose uptake were measured during a hyperinsulinemic euglycemic clamp. Infusion of GLP-1 caused a rapid increase (P

Original language	English
Journal	American Journal of Physiology: Endocrinology and Metabolism
Volume	306
Issue number	4
Pages (from-to)	E355-E362
Number of pages	8
ISSN	0193-1849
DOIs	https://doi.org/10.1152/ajpendo.00283.2013
Publication status	Published - 15 Feb 2014

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AU - Richter, Erik

AU - Kiens, Bente

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PY - 2014/2/15

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N2 - The insulinotropic gut hormone, glucagon-like-peptide-1 (GLP-1) has been proposed to have effects on vascular function and glucose disposal. However, whether GLP-1 is able to increase microvascular recruitment (MVR) in humans has not been investigated. GLP-1 was infused in the femoral artery in overnight fasted healthy young men. Microvascular recruitment was measured with real time contrast-enhanced ultrasound and leg glucose uptake by the leg balance technique with and without inhibition of the insulinotropic response of GLP-1 by co-infusion of octreotide. As a positive control, MVR and leg glucose uptake were measured during a hyperinsulinemic euglycemic clamp. Infusion of GLP-1 caused a rapid increase (P

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GLP-1 increases microvascular recruitment but not glucose uptake in human and rat skeletal muscle

Abstract

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